eCite Digital Repository

Mixed alkoxy/hydroxy 1,8-naphthalimides: expanded fluorescence colour palette and in vitro bioactivity

Citation

Rudebeck, EE and Cox, RP and Bell, TDM and Acharya, R and Feng, Z and Gueven, N and Ashton, TD and Pfeffer, FM, Mixed alkoxy/hydroxy 1,8-naphthalimides: expanded fluorescence colour palette and in vitro bioactivity, Chemical Communications, 56, (50) pp. 6866-6869. ISSN 1359-7345 (2020) [Refereed Article]

Copyright Statement

The Royal Society of Chemistry 2020

DOI: doi:10.1039/d0cc01251c

Abstract

An efficient and functional group tolerant route to access hydroxy 1,8-naphthalimides has been used to synthesise a range of monoand disubstituted hydroxy-1,8-naphthalimides with fluorescence emissions covering the visible spectrum. The dialkoxy substituted compounds prepared possess high quantum yields (up to 0.95) and long fluorescent lifetimes (up to 14 ns). The method has been used to generate scriptaid analogues that successfully inhibit HDAC6 in vitro with tubulin acetylation assays confirming that these compounds are more effective than tubastatin.

Item Details

Item Type:Refereed Article
Keywords:HDAC6 inhibitors
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Pharmaceutical sciences
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Acharya, R (Mr Rameshwor Acharya)
UTAS Author:Feng, Z (Mr Zikai Feng)
UTAS Author:Gueven, N (Dr Nuri Guven)
ID Code:139012
Year Published:2020
Web of Science® Times Cited:4
Deposited By:Pharmacy
Deposited On:2020-05-21
Last Modified:2021-02-11
Downloads:0

Repository Staff Only: item control page