138889 - The Medical Genome Reference Bank.pdf (11.71 MB)
The Medical Genome Reference Bank contains whole genome and phenotype data of 2570 healthy elderly
journal contribution
posted on 2023-05-20, 14:09 authored by Pinese, M, Lacaze, P, Rath, EM, Stone, A, Brion, M-J, Ameur, A, Nagpal, S, Puttick, C, Husson, S, Degrave, D, Cristina, TN, Kahl, VFS, Statham, AL, Woods, RL, McNeil, JJ, Riaz, M, Barr, M, Mark NelsonMark Nelson, Reid, CM, Murray, AM, Shah, RC, Wolfe, R, Atkins, JR, Fitzsimmons, C, Cairns, HM, Green, MJ, Carr, VJ, Cowley, MJ, Pickett, HA, James, PA, Powell, JE, Kaplan, W, Gibson, G, Gyllensten, U, Cairns, MJ, McNamara, M, Dinger, ME, Thomas, DMPopulation health research is increasingly focused on the genetic determinants of healthy ageing, but there is no public resource of whole genome sequences and phenotype data from healthy elderly individuals. Here we describe the first release of the Medical Genome Reference Bank (MGRB), comprising whole genome sequence and phenotype of 2570 elderly Australians depleted for cancer, cardiovascular disease, and dementia. We analyse the MGRB for single-nucleotide, indel and structural variation in the nuclear and mitochondrial genomes. MGRB individuals have fewer disease-associated common and rare germline variants, relative to both cancer cases and the gnomAD and UK Biobank cohorts, consistent with risk depletion. Age-related somatic changes are correlated with grip strength in men, suggesting blood-derived whole genomes may also provide a biologic measure of age-related functional deterioration. The MGRB provides a broadly applicable reference cohort for clinical genetics and genomic association studies, and for understanding the genetics of healthy ageing.
History
Publication title
Nature CommunicationsVolume
11Article number
435Number
435Pagination
1-14ISSN
2041-1723Department/School
Menzies Institute for Medical ResearchPublisher
Nature Pub. GroupPlace of publication
United KingdomRights statement
© The Author(s) 2020. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) http://creativecommons.org/licenses/by/4.0/Repository Status
- Open