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The morphology of proximal tibiofibular joint (PTFJ) predicts incident radiographic osteoarthritis: data from Osteoarthritis Initiative


Chang, J and Zhu, Z and Han, W and Zhao, Y and Kwoh, CK and Lynch, JA and Hunter, DJ and Ding, C, The morphology of proximal tibiofibular joint (PTFJ) predicts incident radiographic osteoarthritis: data from Osteoarthritis Initiative, Osteoarthritis and Cartilage, 28, (2) pp. 208-214. ISSN 1063-4584 (2020) [Refereed Article]

Copyright Statement

Copyright 2019 Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International

DOI: doi:10.1016/j.joca.2019.11.001


Objective: To determine whether the morphology of proximal tibiofibular joint (PTFJ) is associated with increased risk of incident radiographic osteoarthritis (iROA) over 4 years in the OA Initiative (OAI) study.

Methods: A nested matched case-control study design was used to select participants from OAI study. Case knees were defined as those with iROA. Control knees were matched one-to-one by sex, age and radiographic status with case knees. T2-weighted MR images were assessed at P0 (the visit when incident ROA was found on radiograph), P1 (1 year prior to P0) and at OAI baseline. The contacting area of PTFJ (S) and its projection areas onto the horizontal (load-bearing area, Sτ), sagittal (lateral stress-bolstering area, Sφ) and coronal plane (posterior stress-bolstering area, Sυ) were assessed, respectively.

Results: 354 case knees and 354 matched control knees were included, with a mean age of 60 and a mean body mass index (BMI) of 28 kg/m2. Baseline PTFJ morphological parameters (S, Sτ and Sυ) were significantly associated with iROA over 4 years, and these associations remained unchanged after adjustment for BMI, number of knee bending activities, self-reported knee injury and surgery. S, Sτ and Sυ were also significantly associated with iROA at P1 and P0. In subgroup analysed, S, Sτ and Sυ were associated with risks of incident joint space narrowing in the medial, but not the lateral tibiofemoral compartment.

Conclusion: Greater contacting area, load-bearing area and posterior stress-bolstering area of PTFJ were associated with increased risks of iROA, largely in the medial tibiofemoral compartment.

Item Details

Item Type:Refereed Article
Keywords:magnetic resonance image (MRI), osteoarthritis (OA), proximal tibiofibular joint (PTFJ)
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Rheumatology and arthritis
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Zhu, Z (Mr Zhaohua Zhu)
UTAS Author:Han, W (Dr Weiyu Han)
UTAS Author:Ding, C (Professor Chang-Hai Ding)
ID Code:138877
Year Published:2020
Web of Science® Times Cited:8
Deposited By:Menzies Institute for Medical Research
Deposited On:2020-05-06
Last Modified:2020-07-24

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