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Pharmacotherapy for knee osteoarthritis: current and emerging therapies

journal contribution
posted on 2023-05-20, 14:00 authored by Cao, P, Li, Y, Tang, Y, Chang-Hai DingChang-Hai Ding, Hunter, DJ
Introduction: Osteoarthritis (OA) is the leading cause of pain, loss of function and disability in the elderly, with the knee being the most impactful joint affected. Currently, there is still no 'cure' in OA treatment.

Areas covered: The authors review the current and emerging therapies for knee OA including traditional OA medications (oral and topical NSAIDs, acetaminophen, and opioids) and emerging treatments including disease-modifying OA drugs. The failures of agents that have been through clinical trials are also summarized. Furthermore, the authors provide their expert perspectives on the future of pharmacotherapy for knee osteoarthritis.

Expert opinion: Compared to traditional OA medications, new disease-modifying OA drugs that act by reducing inflammation and increasing cartilage repair show promise to address the unmet need of disease modification. Many of these new drugs, however, are in the preclinical stage. Long-term RCTs are expected to identify the safety and efficacy of novel OA pharmacotherapy medicines.

History

Publication title

Expert Opinion on Pharmacotherapy

Volume

21

Issue

7

Pagination

797-809

ISSN

1465-6566

Department/School

Menzies Institute for Medical Research

Publisher

Ashley Publications Ltd

Place of publication

Unitec House, 3Rd Fl, 2 Albert Place, Finchley Central, London, England, N3 1Qb

Rights statement

Copyright 2020 Informa UK Limited, trading as Taylor & Francis Group

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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    University Of Tasmania

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