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The Role of Nucleosomes in Epigenetic Gene Regulation

Citation

Giles, KA and Taberlay, PC, The Role of Nucleosomes in Epigenetic Gene Regulation, Clinical Epigenetics, Springer, Singapore, LB Hesson and AL Pritchard (ed), Singapore, pp. 87-117. ISBN 978-981-13-8957-3 (2019) [Research Book Chapter]

Copyright Statement

Copyright 2019 Springer Nature Singapore Pte Ltd.

DOI: doi:10.1007/978-981-13-8958-0_4

Abstract

Chromatin is a dynamic and highly organised structure that plays a role in all aspects of chromatin biology and controls access to DNA. The basic repeating unit of chromatin is the nucleosome, an octamer of histone proteins wrapped around twice with DNA. Transcriptional gene regulation is largely controlled by the epigenetic regulation of the nucleosome, both through the position of the nucleosome in the DNA and chemical modifications to the histone proteins within the nucleosome core. In this chapter, we discuss the role of the nucleosome in controlling gene regulation at promoters, enhancers and in gene bodies. We also discuss the role of bivalent chromatin and asymmetric nucleosomes at these elements. While the focus of this chapter is on transcriptional regulation, many of the concepts also extend to other aspects of chromatin biology including DNA repair and replication.

Item Details

Item Type:Research Book Chapter
Keywords:nucleosome, gene regulation, acetylation, methylation, promoter, enhancer
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Epigenetics (incl. genome methylation and epigenomics)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Taberlay, PC (Associate Professor Phillippa Taberlay)
ID Code:138623
Year Published:2019
Deposited By:Medicine
Deposited On:2020-04-20
Last Modified:2020-05-20
Downloads:0

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