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If human brain organoids are the answer to understanding dementia, what are the questions?
Citation
Ooi, L and Dottori, M and Cook, AL and Engel, M and Gautam, V and Grubman, A and Hernandez, D and King, AE and Maksour, S and Targa Dias Anastacio, H and Balez, R and Pebay, A and Pouton, C and Valenzuela, M and White, A and Williamson, R, from the Australian Dementia Stem Cell Consortium, If human brain organoids are the answer to understanding dementia, what are the questions?, The Neuroscientist, 26, (5-6) pp. 438-454. ISSN 1073-8584 (2020) [Refereed Article]
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Copyright Statement
© The Author(s) 2020. This is an open access article published under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) license (https://creativecommons.org/licenses/by-nc/4.0/)
DOI: doi:10.1177/1073858420912404
Abstract
Because our beliefs regarding our individuality, autonomy, and personhood are intimately bound up with our brains, there is a public fascination with cerebral organoids, the "mini-brain," the "brain in a dish". At the same time, the ethical issues around organoids are only now being explored. What are the prospects of using human cerebral organoids to better understand, treat, or prevent dementia? Will human organoids represent an improvement on the current, less-than-satisfactory, animal models? When considering these questions, two major issues arise. One is the general challenge associated with using any stem cell-generated preparation for in vitro modelling (challenges amplified when using organoids compared with simpler cell culture systems). The other relates to complexities associated with defining and understanding what we mean by the term "dementia." We discuss 10 puzzles, issues, and stumbling blocks to watch for in the quest to model "dementia in a dish."
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | stem cells, dementia, organoids, induced pluripotent stem cells, Alzheimer’s disease, neurodegeneration, cerebral, cortical, disease model |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Neurosciences |
| Research Field: | Cellular nervous system |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Cook, AL (Associate Professor Tony Cook) |
| UTAS Author: | King, AE (Professor Anna King) |
| ID Code: | 138532 |
| Year Published: | 2020 |
| Web of Science® Times Cited: | 14 |
| Deposited By: | Wicking Dementia Research and Education Centre |
| Deposited On: | 2020-04-14 |
| Last Modified: | 2022-08-23 |
| Downloads: | 14 View Download Statistics |
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