Campbell, JA and Jelinek, GA and Weiland, TJ and Nag, N and Neate, SL and Palmer, AJ and Mulhern, B and De Livera, A and Simpson-Yap, S, SF-6D health state utilities for lifestyle, sociodemographic and clinical characteristics of a large international cohort of people with multiple sclerosis, Quality of Life Research, 29 pp. 2509-2527. ISSN 0962-9343 (2020) [Refereed Article]
© Springer Nature Switzerland AG 2020
Objectives: To derive SF-6D health state utilities (HSUs) for participants of the HOLISM (Health Outcomes and Lifestyle In a Sample of people with Multiple Sclerosis) international cohort and to describe the distribution and determinants thereof.
Methods: HSUs were generated using the SF-6D for participants with sufficient SF-36 data [n = 2185/2466 (88.6%)]. Mean HSUs for sociodemographic, clinical and modifiable lifestyle factors (including diet, physical activity, supplement use) were evaluated. Determinants of HSU were then evaluated by linear regression, adjusted for age, sex, MS type, disability, fatigue, and prescription antidepressant use.
Results: Mean HSU for the sample was 0.67 (SD = 0.13) and diminished with increasing MS-related disability, robust to adjustment, supporting the SF-6D's discriminatory power in people with MS. Severe disability and clinically significant fatigue were each associated with 11% lower HSU (95% CI = - 0.13, - 0.10 and - 0.12, - 0.10), and depression risk with 10%-lower HSU (95% CI = - 0.11, - 0.08). Employment, higher socioeconomic and married/partnered statuses, larger social-network size, greater physical activity, and vitamin D and omega-3 supplement use were associated with significantly higher HSU, and overweight/obese BMI and tobacco smoking with lower HSU. Age, sex, and education were not associated.
Conclusion: Modifiable lifestyle factors including healthy diet, increased physical activity and supplement use were associated with higher HRQOL among people with MS. The SF-6D instrument revealed significant discriminatory power in this international cohort of people with MS.
|Item Type:||Refereed Article|
|Keywords:||quality of life, multiple sclerosis, SF-6D, HOLISM cohort|
|Research Group:||Applied economics|
|Research Field:||Health economics|
|Objective Group:||Evaluation of health and support services|
|Objective Field:||Evaluation of health and support services not elsewhere classified|
|UTAS Author:||Campbell, JA (Dr Julie Campbell)|
|UTAS Author:||Palmer, AJ (Professor Andrew Palmer)|
|UTAS Author:||Simpson-Yap, S (Dr Steve Simpson JR)|
|Web of Science® Times Cited:||4|
|Deposited By:||Menzies Institute for Medical Research|
Repository Staff Only: item control page