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Pathological links between traumatic brain injury and dementia: Australian pre-clinical research
journal contribution
posted on 2023-05-20, 13:26 authored by Jessica CollinsJessica Collins, Adele WoodhouseAdele Woodhouse, Nicole ByeNicole Bye, James VickersJames Vickers, Anna KingAnna King, Jenna ZiebellJenna ZiebellTraumatic brain injury (TBI) can cause persistent cognitive changes and ongoing neurodegeneration in the brain. Accumulating epidemiological and pathological evidence implicates TBI in the development of Alzheimer's disease, the most common cause of dementia. Further, the TBI-induced form of dementia, called chronic traumatic encephalopathy, shares many pathological hallmarks present in multiple different diseases which cause dementia. The inflammatory and neuritic responses to TBI and dementia overlap, indicating that they may share common pathological mechanisms and that TBI may ultimately cause a pathological cascade culminating in the development of dementia. This review explores Australian pre-clinical research investigating the pathological links between TBI and dementia.
History
Publication title
Journal of NeurotraumaVolume
37Issue
5Pagination
782-791ISSN
0897-7151Department/School
Wicking Dementia Research Education CentrePublisher
Mary Ann Liebert Inc PublPlace of publication
2 Madison Avenue, Larchmont, USA, Ny, 10538Rights statement
Copyright 2020 Mary Ann Liebert, Inc.Repository Status
- Restricted