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Pathological links between traumatic brain injury and dementia: Australian pre-clinical research

Citation

Collins, JM and Woodhouse, A and Bye, N and Vickers, JC and King, AE and Ziebell, JM, Pathological links between traumatic brain injury and dementia: Australian pre-clinical research, Journal of Neurotrauma, 37, (5) pp. 782-791. ISSN 0897-7151 (2020) [Refereed Article]


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DOI: doi:10.1089/neu.2019.6906

Abstract

Traumatic brain injury (TBI) can cause persistent cognitive changes and ongoing neurodegeneration in the brain. Accumulating epidemiological and pathological evidence implicates TBI in the development of Alzheimer's disease, the most common cause of dementia. Further, the TBI-induced form of dementia, called chronic traumatic encephalopathy, shares many pathological hallmarks present in multiple different diseases which cause dementia. The inflammatory and neuritic responses to TBI and dementia overlap, indicating that they may share common pathological mechanisms and that TBI may ultimately cause a pathological cascade culminating in the development of dementia. This review explores Australian pre-clinical research investigating the pathological links between TBI and dementia.

Item Details

Item Type:Refereed Article
Keywords:traumatic brain injury, dementia, AD, CTE, microglia, Tau, plaques
Research Division:Medical and Health Sciences
Research Group:Medical Microbiology
Research Field:Medical Microbiology not elsewhere classified
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Behaviour and Health
UTAS Author:Collins, JM (Dr Jessica Collins)
UTAS Author:Woodhouse, A (Dr Adele Woodhouse)
UTAS Author:Bye, N (Dr Nicole Bye)
UTAS Author:Vickers, JC (Professor James Vickers)
UTAS Author:King, AE (Professor Anna King)
UTAS Author:Ziebell, JM (Dr Jenna Ziebell)
ID Code:138356
Year Published:2020
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2020-04-02
Last Modified:2020-04-22
Downloads:0

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