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Effect of Immune Activation during Early Gestation or Late Gestation on Inhibitory Markers in Adult Male Rats


Rahman, T and Weickert, CS and Harms, L and Meehan, C and Schall, U and Todd, J and Hodgson, DM and Michie, PT and Purves-Tyson, T, Effect of Immune Activation during Early Gestation or Late Gestation on Inhibitory Markers in Adult Male Rats, Scientific Reports, 10, (1) ISSN 2045-2322 (2020) [Refereed Article]

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The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

DOI: doi:10.1038/s41598-020-58449-x


People with schizophrenia exhibit deficits in inhibitory neurons and cognition. The timing of maternal immune activation (MIA) may present distinct schizophrenia-like phenotypes in progeny. We investigated whether early gestation [gestational day (GD) 10] or late gestation (GD19) MIA, via viral mimetic polyI:C, produces deficits in inhibitory neuron indices (GAD1, PVALB, SST, SSTR2 mRNAs) within cortical, striatal, and hippocampal subregions of male adult rat offspring. In situ hybridisation revealed that polyI:C offspring had: (1) SST mRNA reductions in the cingulate cortex and nucleus accumbens shell, regardless of MIA timing; (2) SSTR2 mRNA reductions in the cortex and striatum of GD19, but not GD10, MIA; (3) no alterations in cortical or striatal GAD1 mRNA of polyI:C offspring, but an expected reduction of PVALB mRNA in the infralimbic cortex, and; (4) no alterations in inhibitory markers in hippocampus. Maternal IL-6 response negatively correlated with adult offspring SST mRNA in cortex and striatum, but not hippocampus. These results show lasting inhibitory-related deficits in cortex and striatum in adult offspring from MIA. SST downregulation in specific cortical and striatal subregions, with additional deficits in somatostatin-related signalling through SSTR2, may contribute to some of the adult behavioural changes resulting from MIA and its timing.

Item Details

Item Type:Refereed Article
Keywords:somatostatin, schizophrenia, maternal immune activation, inhibitory neuron
Research Division:Psychology
Research Group:Biological psychology
Research Field:Behavioural neuroscience
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in psychology
UTAS Author:Meehan, C (Dr Crystal Meehan)
ID Code:138121
Year Published:2020
Web of Science® Times Cited:6
Deposited By:Psychology
Deposited On:2020-03-25
Last Modified:2021-01-29
Downloads:26 View Download Statistics

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