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A Roadmap for Integrating Neuroscience Into Addiction Treatment: A Consensus of the Neuroscience Interest Group of the International Society of Addiction Medicine


Verdejo-Garcia, A and Lorenzetti, V and Manning, V and Piercy, H and Bruno, R and Hester, R and Pennington, D and Tolomeo, S and Arunogiri, S and Bates, ME and Bowden-Jones, H and Campanella, S and Daughters, SB and Kouimtsidis, C and Lubman, DI and Meyerhoff, DJ and Ralph, A and Rezapour, T and Tavakoli, H and Zare-Bidoky, M and Zilverstand, A and Steele, D and Moeller, SJ and Paulus, M and Baldacchino, A and Ekhtiari, H, A Roadmap for Integrating Neuroscience Into Addiction Treatment: A Consensus of the Neuroscience Interest Group of the International Society of Addiction Medicine, Frontiers in Psychiatry, 10 pp. 1-23. ISSN 1664-0640 (2019) [Refereed Article]


Copyright Statement

Copyright 2019 Verdejo-Garcia, Lorenzetti, Manning, Piercy, Bruno, Hester, Pennington, Tolomeo, Arunogiri, Bates, Bowden-Jones, Campanella, Daughters, Kouimtsidis, Lubman, Meyerhoff, Ralph, Rezapour, Tavakoli, Zare-Bidoky, Zilverstand, Steele, Moeller, Paulus, Baldacchino and Ekhtiari. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

DOI: doi:10.3389/fpsyt.2019.00877


Although there is general consensus that altered brain structure and function underpins addictive disorders, clinicians working in addiction treatment rarely incorporate neuroscience-informed approaches into their practice. We recently launched the Neuroscience Interest Group within the International Society of Addiction Medicine (ISAM-NIG) to promote initiatives to bridge this gap. This article summarizes the ISAM-NIG key priorities and strategies to achieve implementation of addiction neuroscience knowledge and tools for the assessment and treatment of substance use disorders. We cover two assessment areas: cognitive assessment and neuroimaging, and two interventional areas: cognitive training/remediation and neuromodulation, where we identify key challenges and proposed solutions. We reason that incorporating cognitive assessment into clinical settings requires the identification of constructs that predict meaningful clinical outcomes. Other requirements are the development of measures that are easily-administered, reliable, and ecologically-valid. Translation of neuroimaging techniques requires the development of diagnostic and prognostic biomarkers and testing the cost-effectiveness of these biomarkers in individualized prediction algorithms for relapse prevention and treatment selection. Integration of cognitive assessments with neuroimaging can provide multilevel targets including neural, cognitive, and behavioral outcomes for neuroscience-informed interventions. Application of neuroscience-informed interventions including cognitive training/remediation and neuromodulation requires clear pathways to design treatments based on multilevel targets, additional evidence from randomized trials and subsequent clinical implementation, including evaluation of cost-effectiveness. We propose to address these challenges by promoting international collaboration between researchers and clinicians, developing harmonized protocols and data management systems, and prioritizing multi-site research that focuses on improving clinical outcomes.

Item Details

Item Type:Refereed Article
Keywords:addiction medicine, cognitive rehabilitation, fMRI, neuromodulation, neuropsychological assessment, neuroscience, substance use disorder, treatment
Research Division:Psychology
Research Group:Applied and developmental psychology
Research Field:Applied and developmental psychology not elsewhere classified
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Public health (excl. specific population health) not elsewhere classified
UTAS Author:Bruno, R (Associate Professor Raimondo Bruno)
ID Code:138016
Year Published:2019
Web of Science® Times Cited:35
Deposited By:Psychology
Deposited On:2020-03-19
Last Modified:2020-05-22
Downloads:31 View Download Statistics

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