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Association between the FAS/FASL polymorphisms and gastric cancer risk: a meta-analysis


Tian, J and Pan, F and Li, J and Ma, Y and Cen, H and Pan, H-F and Pan, Y-Y and Ye, D-Q, Association between the FAS/FASL polymorphisms and gastric cancer risk: a meta-analysis, Asian Pacific Journal of Cancer Prevention, 13, (3) pp. 945-951. ISSN 1513-7368 (2012) [Refereed Article]

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Copyright Statement

Copyright 2012. Asia Pacific Journal of Cancer Prevention is under the terms of the Creative Commons Attribution License. This permits anyone to copy, distribute, transmit and adapt the published work, provided the original work and source are appropriately cited.

DOI: doi:10.7314/apjcp.2012.13.3.945


Objective: FAS/FASL gene promoter polymorphisms have been repeatedly associated with gastric cancer risk, but findings are inconclusive across studies. To address a more precise estimation of the relationship, a meta-analysis was performed.

Methods: Data were collected from the Pubmed, Medline and EMBASE databases, with the last report up to 1 December, 2011. Crude ORs with 95% CIs were used to assess the strength of the association by (1) the additive, (2) the codominant, (3) the dominant, and (4) the recessive models.

Results: A total of seven studies, including six studies on FAS -1377G>A polymorphism, five studies on FAS -670A>G polymorphism, and six studies on FASL -844T>C polymorphism, were identified in the current meta-analysis. Overall, an association of FAS -1377G>A (AA versus GG: OR = 1.313, 95% CI = 1.045-1.650, Ph = 0.347, I2 = 10.8) and FASL -844T>C (CC versus TT: OR = 1.352, 95% CI = 1.043-1.752, Ph = 0.461, I2 = 0.0) polymorphisms with gastric cancer was found in the codominant model. However, we did not detect any association between gastric cancer and the FAS -670A>G polymorphism. In the subgroup analysis by ethnicity, similar elevated risks were also observed in Asian population for FAS -1377G>A (AA versus GG: OR = 1.309, 95% CI = 1.041- 1.646, Ph = 0.240, I2 = 27.3) and FASL -844T>C (CC versus TT: OR = 1.420, 95% CI = 1.081-1.865, Ph = 0.524, I2 = 0.0) polymorphisms.

Conclusions: This meta-analysis indicated that FAS -1377G>A and FASL -844T>C polymorphisms might be associated with gastric cancer risk.

Item Details

Item Type:Refereed Article
Keywords:gastric cancer, FAS, FASL, polymorphism, meta-analysis
Research Division:Biomedical and Clinical Sciences
Research Group:Oncology and carcinogenesis
Research Field:Cancer cell biology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Pan, F (Dr Feng Pan)
ID Code:137964
Year Published:2012
Web of Science® Times Cited:11
Deposited By:Menzies Institute for Medical Research
Deposited On:2020-03-17
Last Modified:2020-04-29
Downloads:15 View Download Statistics

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