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Distal radius bone microarchitecture: what are the differences between age 25 and old age?

Citation

Ma, C and Pan, F and Yang, Y and Laslett, L and Squibb, K and Zebaze, R and Winzenberg, T and Jones, G, Distal radius bone microarchitecture: what are the differences between age 25 and old age?, Archives of Osteoporosis, 15, (1) Article 16. ISSN 1862-3522 (2020) [Refereed Article]


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Copyright Statement

Copyright International Osteoporosis Foundation and National Osteoporosis Foundation 2020. Post-prints are subject to Springer Nature re-use terms

DOI: doi:10.1007/s11657-020-0696-9

Abstract

Summary: This study reported that the transitional zones in older adults were enlarged at the expense of the compact-appearing cortex with a greater porosity in all cortical sub-compartments. The magnitude of differences in areal and volumetric bone mineral density (aBMD, vBMD) between older and younger groups was similar.

Introduction: Aging is strongly associated with bone loss, but little is known about magnitudes of differences in bone microarchitectures, aBMD, and vBMD from peak bone mass (PBM) to senescence. We aimed to describe differences in aBMD, vBMD, and bone microarchitecture parameters at the distal radius between older and young adults.

Methods: We compared 201 participants, aged 62-89 years (female 47%) and 196 participants, aged 24-28 years (female 38%). Bone microarchitecture parameters at distal radius were measured using high-resolution peripheral computed tomography (HRpQCT). aBMD was measured using dual-energy X-ray absorptiometry (DXA). Unpaired t tests and chi-square tests were used to compare differences in means and proportions as appropriate.

Results: Older adults had thinner compact-appearing cortices with larger (cross-sectional area: outer 30.96 mm2 vs. 28.38 mm2, inner 36.34 mm2 vs. 32.93 mm2) and thicker (outer 0.57 mm vs. 0.54 mm, inner 0.71 mm vs. 0.65 mm) transitional zones compared with young adults (all p < 0.05). Cortical porosity was modestly higher in older adults than in young adults (54% vs. 49%, p < 0.001). The magnitude of the difference in hip aBMD between older and young adults was slightly lower than of total radial vBMD (- 0.51 SD vs. - 0.78 SD).

Conclusion: Compared with young adults at the time of PBM, the transitional zones in older adults were enlarged at the expense of the compact-appearing cortex with a greater porosity in all cortical sub-compartments. The similar SD differences in aBMD and vBMD between older and younger groups suggest that the differences in bone area are not leading to major artefactual change in aBMD.

Item Details

Item Type:Refereed Article
Keywords:bone microarchitecture, bone mineral density, high-resolution peripheral quantitative computed tomography, peak bone mass
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Epidemiology not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Ma, C (Miss Canchen Ma)
UTAS Author:Pan, F (Dr Feng Pan)
UTAS Author:Yang, Y (Miss Yi Yang)
UTAS Author:Laslett, L (Dr Laura Laslett)
UTAS Author:Squibb, K (Dr Kathryn Squibb)
UTAS Author:Winzenberg, T (Professor Tania Winzenberg)
UTAS Author:Jones, G (Professor Graeme Jones)
ID Code:137839
Year Published:2020
Deposited By:Menzies Institute for Medical Research
Deposited On:2020-03-06
Last Modified:2020-04-08
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