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Compatibility and stability of fentanyl admixtures in polypropylene syringes


Peterson, GM and Miller, KAL and Galloway, JG and Dunne, PF, Compatibility and stability of fentanyl admixtures in polypropylene syringes, Journal of Clinical Pharmacy and Therapeutics, 23, (1) pp. 67-72. ISSN 0269-4727 (1998) [Refereed Article]

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DOI: doi:10.1046/j.1365-2710.1998.00141.x


Objective: To determine the physicochemical stability of fentanyl in combination with midazolam and either hyoscine butylbromide or metoclo- pramide, and stored in 30 ml polypropylene syringes. Methods: Solutions containing approximately 40 g/ml of fentanyl in combination with midazolam (approximately 600 g/ml) and either metoclopramide (approximately 700 g/l) or hyoscine (approximately 850 g/ml) were prepared from commercial ampoules of the drugs. The solutions were stored, in triplicate, in the dark at 32 C (to simulate usage conditions) for 10 days, and the concentration of each constituent drug was periodically determined using a stability-indicating high-performance liquid chromatography assay. Results: The combinations were relatively stable, with all drugs maintaining over 90% of their initial chemical potency for at least 1 week. There were no evident changes in either the physical appearance or pH values of the solutions over the course of the study. Conclusions: On the basis of physicochemical stability, polypropylene syringes containing fentanyl with midazolam and either hyoscine butylbromide or metoclopramide can be safely prepared and stored at or below 32 C for periods of up to 1 week prior to use by palliative care patients receiving the drugs via a portable subcutaneous infusion device.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacology and therapeutics
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Peterson, GM (Professor Gregory Peterson)
UTAS Author:Miller, KAL (Ms Miller)
ID Code:13775
Year Published:1998
Web of Science® Times Cited:13
Deposited By:Pharmacy
Deposited On:1998-08-01
Last Modified:2011-06-03
Downloads:6 View Download Statistics

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