eCite Digital Repository

Micro RNA expression after ingestion of fucoidan; a clinical study

Citation

Guven, N and Spring, KJ and Holmes, S and Ahuja, K and Eri, R and Park, AY and Fitton, JH, Micro RNA expression after ingestion of fucoidan; a clinical study, Marine Drugs, 18, (3) pp. 1-11. ISSN 1660-3397 (2020) [Refereed Article]


Preview
PDF (Published version)
411Kb
  

Copyright Statement

2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

DOI: doi:10.3390/md18030143

Abstract

Fucoidans are a class of fucose‐rich sulfated polysaccharides derived from brown macroalgae that exert a range of biological activities in vitro and in vivo. To generate an unbiased assessment of pathways and processes affected by fucoidan, a placebo‐controlled double‐blind pilot study was performed in healthy volunteers. Blood samples were taken immediately before and 24 h after ingestion of a single dose of 1 g of Undaria pinnatifida fucoidan (UPF) or placebo. Levels of isolated miRNAs were analyzed using Taqman Open Array Human MicroRNA panels. Out of 754 miRNAs screened, UPF affected a total of 53 miRNAs. Pathway analysis using the TALOS data analysis tool predicted 29 different pathways and processes that were largely grouped into cell surface receptor signaling, cancer‐related pathways, the majority of which were previously associated with fucoidans. However, this analysis also identified nine pathways and processes that have not been associated with fucoidans before. Overall, this study illustrates that even a single dose of fucoidans has the potential to affect the expression of genes related to fundamental cellular processes. Moreover, it confirms previous data that fucoidans influence immunity, cancer cells, inflammation, and neurological function.

Item Details

Item Type:Refereed Article
Keywords:fucoidan, miRNA, clinical study
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacology and therapeutics
Objective Division:Health
Objective Group:Other health
Objective Field:Other health not elsewhere classified
UTAS Author:Guven, N (Dr Nuri Guven)
UTAS Author:Holmes, S (Mrs Sandra Holmes)
UTAS Author:Ahuja, K (Dr Kiran Ahuja)
UTAS Author:Eri, R (Associate Professor Raj Eri)
ID Code:137743
Year Published:2020
Web of Science® Times Cited:4
Deposited By:Pharmacy
Deposited On:2020-03-02
Last Modified:2021-01-27
Downloads:7 View Download Statistics

Repository Staff Only: item control page