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Micro RNA expression after ingestion of fucoidan; a clinical study
Citation
Guven, N and Spring, KJ and Holmes, S and Ahuja, K and Eri, R and Park, AY and Fitton, JH, Micro RNA expression after ingestion of fucoidan; a clinical study, Marine Drugs, 18, (3) pp. 1-11. ISSN 1660-3397 (2020) [Refereed Article]
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Copyright Statement
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Abstract
Fucoidans are a class of fucose‐rich sulfated polysaccharides derived from brown
macroalgae that exert a range of biological activities in vitro and in vivo. To generate an unbiased
assessment of pathways and processes affected by fucoidan, a placebo‐controlled double‐blind pilot
study was performed in healthy volunteers. Blood samples were taken immediately before and 24
h after ingestion of a single dose of 1 g of Undaria pinnatifida fucoidan (UPF) or placebo. Levels of
isolated miRNAs were analyzed using Taqman Open Array Human MicroRNA panels. Out of 754
miRNAs screened, UPF affected a total of 53 miRNAs. Pathway analysis using the TALOS data
analysis tool predicted 29 different pathways and processes that were largely grouped into cell
surface receptor signaling, cancer‐related pathways, the majority of which were previously
associated with fucoidans. However, this analysis also identified nine pathways and processes that
have not been associated with fucoidans before. Overall, this study illustrates that even a single dose
of fucoidans has the potential to affect the expression of genes related to fundamental cellular
processes. Moreover, it confirms previous data that fucoidans influence immunity, cancer cells,
inflammation, and neurological function.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | fucoidan, miRNA, clinical study |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Pharmacology and pharmaceutical sciences |
| Research Field: | Clinical pharmacology and therapeutics |
| Objective Division: | Health |
| Objective Group: | Other health |
| Objective Field: | Other health not elsewhere classified |
| UTAS Author: | Guven, N (Dr Nuri Guven) |
| UTAS Author: | Holmes, S (Mrs Sandra Holmes) |
| UTAS Author: | Ahuja, K (Dr Kiran Ahuja) |
| UTAS Author: | Eri, R (Associate Professor Raj Eri) |
| ID Code: | 137743 |
| Year Published: | 2020 |
| Web of Science® Times Cited: | 13 |
| Deposited By: | Pharmacy |
| Deposited On: | 2020-03-02 |
| Last Modified: | 2021-01-27 |
| Downloads: | 21 View Download Statistics |
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