Zhao, B and Johnston, FH and O'Sullivan, T and Williamson, G and Melody, S and Dalton, M and Venn, A and Negishi, K, Early life exposure to coal mine fire and tobacco smoke affect subclinical vascular function, Archives of Disease in Childhood, 105, (6) pp. 539-544. ISSN 0003-9888 (2020) [Refereed Article]
© Author(s) (or their employer(s)) 2019.
Objective: To evaluate whether vascular health in young children was associated with exposure to a 6-week episode of coal mine fire smoke or environmental tobacco smoke (ETS) in a retrospective cohort study.
Methods: Three years after a coal mine fire in Victoria, Australia, we investigated the vascular health of children either in utero (n = 75) or aged < 2 years (postnatal exposure, n = 96) at the time of the fire. The outcomes were the carotid intima-media thickness (IMT) and pulse wave velocity (PWV). The mean and peak daily particulate matter < 2.5 µm in diameter (PM2.5) exposures were estimated based on their daily locations throughout the fire period. Multivariable linear regression models were used to test for associations between the fire-related PM2.5 and outcomes adjusted for relevant covariates including ETS.
Results: In the postnatal-exposure group, each 10 µg/m3 increase in mean PM2.5 level was independently positively associated with PWV (β = 0.116, p = 0.028). When these two groups were combined, there was an association between mean PM2.5 and increased PWV in those children who had ETS exposure (β = 0.148, p = 0.033) or whose mothers smoked (β = 0.151, p = 0.011), but not in those not exposed to ETS or maternal smoking.
Conclusions: Three years after a coal mine fire, infants aged up to 2 years at the time of exposure have increases in vascular stiffness. Although no adverse effects were observed in the in uterus exposure group, further follow-up study is needed to elucidate the long-term effects of coal mine fire smoke exposure.
|Item Type:||Refereed Article|
|Keywords:||smoke, tobacco, pollution, child health, vascular|
|Research Division:||Health Sciences|
|Research Group:||Public health|
|Research Field:||Community child health|
|Objective Group:||Specific population health (excl. Indigenous health)|
|Objective Field:||Neonatal and child health|
|UTAS Author:||Zhao, B (Miss Bing Zhao)|
|UTAS Author:||Johnston, FH (Professor Fay Johnston)|
|UTAS Author:||O'Sullivan, T (Miss Tierney O'Sullivan)|
|UTAS Author:||Williamson, G (Dr Grant Williamson)|
|UTAS Author:||Melody, S (Dr Shannon Melody)|
|UTAS Author:||Dalton, M (Ms Marita Dalton)|
|UTAS Author:||Venn, A (Professor Alison Venn)|
|UTAS Author:||Negishi, K (Dr Kazuaki Negishi)|
|Year Published:||2020 (online first 2019)|
|Web of Science® Times Cited:||5|
|Deposited By:||Plant Science|
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