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Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice

Citation

Wang, S and Ahmadi, S and Nagpal, R and Jain, S and Mishra, SP and Kavanagh, K and Zhu, X and Wang, Z and McClain, DA and Kritchevsky, SB and Kitzman, DW and Yadav, H, Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice, GeroScience, 42 pp. .333-352. ISSN 2509-2715 (2019) [Refereed Article]

Copyright Statement

Copyright 2019 American Aging Association

DOI: doi:10.1007/s11357-019-00137-4

Abstract

Increased inflammation associated with leaky gut is a major risk factor for morbidity and mortality in older adults; however, successful preventive and therapeutic strategies against these conditions are not available. In this study, we demonstrate that a human-origin Lactobacillus paracasei D3-5 strain (D3-5), even in the non-viable form, extends life span of Caenorhabditis elegans. In addition, feeding of heat-killed D3-5 to old mice (> 79 weeks) prevents high- fat diet-induced metabolic dysfunctions, decreases leaky gut and inflammation, and improves physical and cognitive functions. D3-5 feeding significantly increases mucin production, and proportionately, the abundance of mucin-degrading bacteria Akkermansia muciniphila also increases. Mechanistically, we show that the lipoteichoic acid (LTA), a cell wall component of D3-5, enhances mucin (Muc2) expression by modulating TLR-2/p38-MAPK/NF-kB pathway, which in turn reduces age-related leaky gut and inflammation. The findings indicate that the D3-5 and its LTA can prevent/treat age-related leaky gut and inflammation.

Item Details

Item Type:Refereed Article
Keywords:aging, cell wall, cognition, goblet cell, inflammation, leaky gut, lipoteichoic acid, metabolism, mucin, probiotics, physical function
Research Division:Biomedical and Clinical Sciences
Research Group:Nutrition and dietetics
Research Field:Nutritional science
Objective Division:Health
Objective Group:Specific population health (excl. Indigenous health)
Objective Field:Health related to ageing
UTAS Author:Kavanagh, K (Associate Professor Kylie Kavanagh)
ID Code:137527
Year Published:2019
Web of Science® Times Cited:28
Deposited By:Medicine
Deposited On:2020-02-19
Last Modified:2020-05-13
Downloads:0

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