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Modification of macrophage response to lipopolysaccharide by fetuin


Dziegielewska, KM and Andersen, NA and Saunders, NR, Modification of macrophage response to lipopolysaccharide by fetuin, Immunology Letters, 60, (1) pp. 31-35. ISSN 0165-2478 (1998) [Refereed Article]

DOI: doi:10.1016/S0165-2478(97)00126-0


The physiological role(s) of fetuin, a protein present in plasma and many tissues of developing animals at levels much higher than in the adult, is unknown. Here we show that fetuin can modify the responses of macrophages to lipopolysaccharide (LPS) stimulation. At concentrations of fetuin in the medium, corresponding to fetal levels of this protein in plasma, the production and secretion of interleukin 1β (IL-1β) and nitric oxide (NO) is almost abolished, tumour necrosis factor-alpha (TNF-α) reduced, while that of IL-6 is not affected. On the other hand, concentrations of fetuin corresponding to adult plasma levels (i.e, 40-60 mg/100 ml) were without much effect on macrophage synthesis and secretion of these cytokines.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the environmental sciences
UTAS Author:Dziegielewska, KM (Dr Kate Dziegielewska)
UTAS Author:Andersen, NA (Dr Niels Andersen)
UTAS Author:Saunders, NR (Professor Norman Saunders)
ID Code:13737
Year Published:1998
Web of Science® Times Cited:45
Deposited By:Anatomy and Physiology
Deposited On:1998-08-01
Last Modified:2011-08-08

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