Oates, J and Davies, S and Roydhouse, J and Fethney, J and White, K, The effect of cancer stage and treatment modality on quality of life in oropharyngeal cancer, Laryngoscope, 124, (1) pp. 151-158. ISSN 0023-852X (2014) [Refereed Article]
Copyright 2013 The American Laryngological, Rhinological and Otological Society, Inc.
Study Design: Individual prospective cohort study.
Methods: All newly diagnosed patients with oropharyngeal cancer treated with curative intent were routinely assessed. The European Organization for Research and Treatment of Cancer (EORTC) both the Main Module quality-of-life questionnaire (QLQ-C30) and the Head and Neck Cancer (HNC) Module (QLQ-H&N35) were administered at diagnosis and 3, 6, and 12 months thereafter. Complete case analysis was used following assessment of missing data. The proportion of patients with clinically significant deterioration (changes of ≥ 10 points) from baseline were calculated for each follow-up time point and compared by stage (I/II vs. III/IV) and then treatment type (chemotherapy and radiotherapy [CRT] vs. surgery and postoperative radiotherapy [S&PORT]).
Results: Deterioration in most domains was most frequent for stage III/IV patients at 3 months (both modules), whereas stage I/II patients experienced this at 6 months (QLQ-C30) and 12 months (H&N35). Among stage III/IV patients, this happened at all time points for S&PORT patients (QLQ-C30) versus 12 months for CRT patients (H&N35). The number of patients reporting deterioration was lower for most domains at 12 months compared to earlier periods, although dry mouth remained a problem for most patients (60%-85% across treatment/stage groups).
Conclusions: Our preliminary findings suggest that general and disease-specific deterioration is of most concern for stage I/II patients at 6 and 12 months and at 3 months for advanced cancer patients. For stage III/IV patients receiving S&PORT, general deterioration remains a problem after diagnosis, whereas for CRT patients, disease-specific deterioration is of most concern at 12 months.
|Item Type:||Refereed Article|
|Keywords:||oropharyngeal cancer, quality of life, surgery, radiotherapy, head and neck cancer|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Oncology and carcinogenesis|
|Research Field:||Oncology and carcinogenesis not elsewhere classified|
|Objective Group:||Evaluation of health and support services|
|Objective Field:||Evaluation of health outcomes|
|UTAS Author:||Roydhouse, J (Dr Jessica Roydhouse)|
|Web of Science® Times Cited:||12|
|Deposited By:||Menzies Institute for Medical Research|
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