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Permeability of the developing and mature blood-brain barriers to the theophylline in rats


Habgood, MD and Knott, GW and Dziegielewska, KM and Saunders, NR, Permeability of the developing and mature blood-brain barriers to the theophylline in rats, Clinical and Experimental Pharmacology and Physiology, 25, (5) pp. 361-368. ISSN 0305-1870 (1998) [Refereed Article]

DOI: doi:10.1111/j.1440-1681.1998.tb02364.x


1. In the present study, the uptake of theophylline and L-glucose into the adult and neonatal rat brain has been investigated. Steady state cerebrospinal fluid (CSF) and brain concentrations of theophylline were reached within 1 h following a single intraperitonenl (i.p.) injection, whereas steady state CSF and brain concentrations of L-glucose were not approached until after 5 h. 2. Steady state brain:plasma and CSF:plasma concentration ratios for theophylline and L-glucose in neonatal rats were significantly higher than ratios in adult rats. Erythrocyte:plasma ratios for theophylline in neonatal rats were also significantly higher than ratios in adult rats. Steady state ratios for theophylline were significantly higher than those for L-glucose in both neonatal and adult rats. 3. Respiratory acidosis (pH 6.9-7.0) did not affect steady state CSF:plasma or brain:plasma ratios for theophylline in neonatal or adult rats. In contrast, steady state CSF:plasma and brain:plasma ratios for L-glucose were increased by respiratory acidosis. 4. The lower steady state CSF:plasma, brain:plasma and erythrocyte:plasma ratios for theophylline in adult rats are likely to be due to a higher concentration of plasma proteins in adult blood compared with neonates, with a greater retention of protein-bound (non-exchangeable) theophylline in adult blood, and are unlikely to be due to p-glycoprotein-mediated efflux of theophylline at the adult blood-brain barrier.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Health
Objective Group:Other health
Objective Field:Other health not elsewhere classified
UTAS Author:Habgood, MD (Dr Mark Habgood)
UTAS Author:Knott, GW (Dr Graham Knott)
UTAS Author:Dziegielewska, KM (Dr Kate Dziegielewska)
UTAS Author:Saunders, NR (Professor Norman Saunders)
ID Code:13736
Year Published:1998
Web of Science® Times Cited:17
Deposited By:Anatomy and Physiology
Deposited On:1998-08-01
Last Modified:2011-08-08

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