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Permeability of the developing and mature blood-brain barriers to the theophylline in rats
Citation
Habgood, MD and Knott, GW and Dziegielewska, KM and Saunders, NR, Permeability of the developing and mature blood-brain barriers to the theophylline in rats, Clinical and Experimental Pharmacology and Physiology, 25, (5) pp. 361-368. ISSN 0305-1870 (1998) [Refereed Article]
DOI: doi:10.1111/j.1440-1681.1998.tb02364.x
Abstract
1. In the present study, the uptake of theophylline and L-glucose into the adult and neonatal rat brain has been investigated. Steady state cerebrospinal fluid (CSF) and brain concentrations of theophylline were reached within 1 h following a single intraperitonenl (i.p.) injection, whereas steady state CSF and brain concentrations of L-glucose were not approached until after 5 h. 2. Steady state brain:plasma and CSF:plasma concentration ratios for theophylline and L-glucose in neonatal rats were significantly higher than ratios in adult rats. Erythrocyte:plasma ratios for theophylline in neonatal rats were also significantly higher than ratios in adult rats. Steady state ratios for theophylline were significantly higher than those for L-glucose in both neonatal and adult rats. 3. Respiratory acidosis (pH 6.9-7.0) did not affect steady state CSF:plasma or brain:plasma ratios for theophylline in neonatal or adult rats. In contrast, steady state CSF:plasma and brain:plasma ratios for L-glucose were increased by respiratory acidosis. 4. The lower steady state CSF:plasma, brain:plasma and erythrocyte:plasma ratios for theophylline in adult rats are likely to be due to a higher concentration of plasma proteins in adult blood compared with neonates, with a greater retention of protein-bound (non-exchangeable) theophylline in adult blood, and are unlikely to be due to p-glycoprotein-mediated efflux of theophylline at the adult blood-brain barrier.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Medical and Health Sciences |
| Research Group: | Neurosciences |
| Research Field: | Central Nervous System |
| Objective Division: | Health |
| Objective Group: | Other Health |
| Objective Field: | Health not elsewhere classified |
| Author: | Habgood, MD (Dr Mark Habgood) |
| Author: | Knott, GW (Dr Graham Knott) |
| Author: | Dziegielewska, KM (Dr Kate Dziegielewska) |
| Author: | Saunders, NR (Professor Norman Saunders) |
| ID Code: | 13736 |
| Year Published: | 1998 |
| Web of Science® Times Cited: | 14 |
| Deposited By: | Anatomy and Physiology |
| Deposited On: | 1998-08-01 |
| Last Modified: | 2011-08-08 |
| Downloads: | 0 |
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