Bjorklund, E and Maya, F and Bak, SA and Hansen, M and Estela, JM and Cerda, V, Possibilities and limitations of the sequential injection chromatography technique for the determination of anticoccidial agents in water, pharmaceutical formulations and feed, Microchemical Journal, 98 pp. 190-199. ISSN 0026-265X (2011) [Refereed Article]
© 2011 Elsevier B.V. All rights reserved.
This paper explores the potential of applying reversed-phase sequential injection chromatography (SIC) to determine the anticoccidial agents Lasalocid and Toltrazuril in various matrices including ground water, pharmaceutical formulations and feed. SIC was performed by connecting a 25 × 4.6 mm monolithic C18 column to a 2 m long pathlength capillary flow cell, where the usage of a flow cell lowers the detection limit compared to a conventional short-distance flow cell, providing a simple detection system for these two compounds which are initially poorly UV absorbents.
The proposed set-up provides a high injection throughput of 12 h− 1, as well as a limit of detection of 0.019 and 0.010 mg/L for Toltrazuril and Lasalocid, respectively. The repeatabilities obtained (n = 10) were lower than 2% and 4% for Toltrazuril and Lasalocid, respectively.
|Item Type:||Refereed Article|
|Keywords:||flow analysis, chromatography|
|Research Division:||Chemical Sciences|
|Research Group:||Analytical chemistry|
|Research Field:||Flow analysis|
|Objective Division:||Expanding Knowledge|
|Objective Group:||Expanding knowledge|
|Objective Field:||Expanding knowledge in the chemical sciences|
|UTAS Author:||Maya, F (Mr Fernando Maya Alejandro)|
|Web of Science® Times Cited:||10|
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