eCite Digital Repository

The fetal glycoprotein, fetuin, counteracts ill-effects of the bacterial endotoxin, lipopolysaccharide, in pregnancy

Citation

Dziegielewska, KM and Andersen, NA, The fetal glycoprotein, fetuin, counteracts ill-effects of the bacterial endotoxin, lipopolysaccharide, in pregnancy, Biology of the Neonate, 74, (5) pp. 372-375. ISSN 0006-3126 (1998) [Refereed Article]

DOI: doi:10.1159/000014055

Abstract

We show that fetuin, a fetal glycoprotein present in fetal plasma in concentrations substantially higher than in the adult, can exert a protective function against ill-effects of the bacterial endotoxin, lipopolysaccharide (LPS), in pregnancy. The concentration of fetuin in plasma of pregnant rats (E17 gestation) was artificially increased by repeated intraperitoneal administration of this protein. This was followed by an injection of a standard dose of LPS, a dose that produced in control animals (no additional fetuin) nearly 50% abortions and 40% maternal deaths. None of the females exposed to increased fetuin died following LPS injection. Nine out of 10 multigravida animals carried their pregnancy to full term but all primagravidas aborted.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Immunology
Research Field:Immunology not elsewhere classified
Objective Division:Health
Objective Group:Other Health
Objective Field:Health not elsewhere classified
Author:Dziegielewska, KM (Dr Kate Dziegielewska)
Author:Andersen, NA (Dr Niels Andersen)
ID Code:13730
Year Published:1998
Web of Science® Times Cited:9
Deposited By:Anatomy and Physiology
Deposited On:1998-08-01
Last Modified:2011-08-08
Downloads:0

Repository Staff Only: item control page