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EMT signaling: potential contribution of CRISPR/Cas gene editing

Citation

Mohammadinejad, R and Biagioni, A and Arunkumar, G and Shapiro, R and Chang, KC and Sedeeq, M and Taiyab, A and Hashemabadi, M and Pardakhty, A and Mandegary, A and Thiery, JP and Aref, AR and Azimi, I, EMT signaling: potential contribution of CRISPR/Cas gene editing, Cellular and Molecular Life Sciences ISSN 1420-682X (2020) [Substantial Review]


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DOI: doi:10.1007/s00018-020-03449-3

Abstract

Epithelial to mesenchymal transition (EMT) is a complex plastic and reversible cellular process that has critical roles in diverse physiological and pathological phenomena. EMT is involved in embryonic development, organogenesis and tissue repair, as well as in fbrosis, cancer metastasis and drug resistance. In recent years, the ability to edit the genome using the clustered regularly interspaced palindromic repeats (CRISPR) and associated protein (Cas) system has greatly contributed to identify or validate critical genes in pathway signaling. This review delineates the complex EMT networks and discusses recent studies that have used CRISPR/Cas technology to further advance our understanding of the EMT process.

Item Details

Item Type:Substantial Review
Keywords:epithelial–mesenchymal transition, CRISPR, gene editing, cancer
Research Division:Biomedical and Clinical Sciences
Research Group:Oncology and carcinogenesis
Research Field:Cancer cell biology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Sedeeq, M (Mr Mohammed Sedeeq)
UTAS Author:Azimi, I (Dr Iman Azimi)
ID Code:137283
Year Published:2020
Web of Science® Times Cited:8
Deposited By:Pharmacy
Deposited On:2020-02-07
Last Modified:2020-02-18
Downloads:0

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