French, J and van der Mei, I and Simpson Jr, S and Ng, J and Angus, P and Lubel, J and Nicoll, A and Sood, S and Roberts, SK and Kemp, W and Arachchi, N and Dev, A and Thompson, A and Gow, PJ, Increasing prevalence of primary biliary cholangitis in Victoria, Australia, Journal of Gastroenterology and Hepatology pp. 1-7. ISSN 0815-9319 (2019) [Refereed Article]
© 2019 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd
Methods: Four case-finding methods were used to identify cases of PBC in Victoria: (1) physicians' survey; (2) tertiary hospital search; (3) liver transplant database search; and (4) private pathology antimitochondrial antibody search.
Results: The prevalence of PBC in Victoria, Australia, is 189.0 per million using all four methods. The average annual increase in prevalence from 1991 to 2013 was 7.7 per million per year. Using the same case-finding methods as the 1991 Victorian prevalence study (methods 1 and 2), the prevalence of PBC increased from 19.1 per million in 1991 to 49.4 per million in 2002 (P < 0.001) and to 80.7 per million in 2013 (P < 0.001).
Conclusions: The current prevalence of PBC in Victoria is significantly higher than previously reported. The use of private pathology-based case-finding methods is important in identifying the maximum number of PBC cases.
|Item Type:||Refereed Article|
|Keywords:||autoimmune liver disease, epidemiology, primary biliary cirrhosis|
|Research Division:||Medical and Health Sciences|
|Research Group:||Public Health and Health Services|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Immune System and Allergy|
|UTAS Author:||van der Mei, I (Associate Professor Ingrid van der Mei)|
|UTAS Author:||Simpson Jr, S (Dr Steve Simpson JR)|
|Deposited By:||Menzies Institute for Medical Research|
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