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Increasing prevalence of primary biliary cholangitis in Victoria, Australia


French, J and van der Mei, I and Simpson Jr, S and Ng, J and Angus, P and Lubel, J and Nicoll, A and Sood, S and Roberts, SK and Kemp, W and Arachchi, N and Dev, A and Thompson, A and Gow, PJ, Increasing prevalence of primary biliary cholangitis in Victoria, Australia, Journal of Gastroenterology and Hepatology pp. 1-7. ISSN 0815-9319 (2019) [Refereed Article]

Copyright Statement

2019 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd

DOI: doi:10.1111/jgh.14924


Background and Aim: The prevalence of primary biliary cholangitis (PBC) reported in different countries varies significantly and in some parts of the world appears to be increasing. The aim of this study was to determine the 2013 prevalence of PBC in Victoria, Australia, and to determine the time trend by comparing it with previous studies undertaken in 1991 and 2002.

Methods: Four case-finding methods were used to identify cases of PBC in Victoria: (1) physicians' survey; (2) tertiary hospital search; (3) liver transplant database search; and (4) private pathology antimitochondrial antibody search.

Results: The prevalence of PBC in Victoria, Australia, is 189.0 per million using all four methods. The average annual increase in prevalence from 1991 to 2013 was 7.7 per million per year. Using the same case-finding methods as the 1991 Victorian prevalence study (methods 1 and 2), the prevalence of PBC increased from 19.1 per million in 1991 to 49.4 per million in 2002 (P < 0.001) and to 80.7 per million in 2013 (P < 0.001).

Conclusions: The current prevalence of PBC in Victoria is significantly higher than previously reported. The use of private pathology-based case-finding methods is important in identifying the maximum number of PBC cases.

Item Details

Item Type:Refereed Article
Keywords:autoimmune liver disease, epidemiology, primary biliary cirrhosis
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Epidemiology not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:van der Mei, I (Professor Ingrid van der Mei)
UTAS Author:Simpson Jr, S (Dr Steve Simpson JR)
ID Code:137229
Year Published:2019
Web of Science® Times Cited:4
Deposited By:Menzies Institute for Medical Research
Deposited On:2020-02-05
Last Modified:2020-03-26

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