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Associations of childhood adiposity and changes in adiposity status from childhood to adulthood with pregnancy hypertension
Citation
He, Y and Tian, J and Blizzard, L and Oddy, WH and Dwyer, T and Venn, AJ, Associations of childhood adiposity and changes in adiposity status from childhood to adulthood with pregnancy hypertension, Pregnancy Hypertension, 19 pp. 218-225. ISSN 2210-7789 (2020) [Refereed Article]
Copyright Statement
Copyright 2019 International Society for the Study of Hypertension in Pregnancy
DOI: doi:10.1016/j.preghy.2019.11.006
Abstract
Study Design: The study followed-up 985 girls from the 1985 Australian Schools Health and Fitness Survey (aged 9-15 years) who were ever pregnant in 2004-2006 and/or 2009-2011. In childhood, overweight and obesity were defined by age-sex-specific international standard for body mass index (BMI) and in adulthood as BMI ≥ 25 kg/m2. Childhood and adult abdominal obesity were defined as waist-to-height ratio (WHtR) ≥ 0.5. A subsample of adults had abdominal obesity measures (n = 549).
Main Outcome Measures: Pregnancy hypertension was self-reported as having had high blood pressure during or due to pregnancy.
Results: Childhood overweight/obesity (relative risk [RR] = 1.66, 95% confidence interval [CI]:1.07-2.52) and abdominal obesity (RR = 2.55, 95% CI:1.34-4.85) were associated with higher risks of pregnancy hypertension after adjustment for age, socioeconomic status and parity. Further adjustment for adult BMI attenuated the association for childhood overweight/obesity which was no longer statistically significant (RR = 1.28, 95% CI:0.79-2.07). The association with childhood abdominal obesity persisted after adjustment for adult WHtR (RR = 2.15, 95% CI:1.10-4.20). Compared to participants with persistently normal BMI or WHtR, those who were overweight/obese in adulthood only (RR = 1.49, 95% CI:1.10-2.02), persistently overweight/obese (RR = 2.06, 95% CI:1.29-3.29) or persistently abdominally obese (RR = 3.09, 95% CI:1.54-6.20) had increased risks of pregnancy hypertension.
Conclusion(s): Childhood adiposity was associated with increased risk of pregnancy hypertension, with the association of childhood abdominal obesity independent of adult abdominal obesity. Women who were persistently overweight/obese or abdominally obese since childhood had the highest risk of pregnancy hypertension.
Item Details
Item Type: | Refereed Article |
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Keywords: | abdominal obesity, body mass index, childhood, pregnancy hypertension, waist-to-height ratio |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Cardiovascular medicine and haematology |
Research Field: | Cardiology (incl. cardiovascular diseases) |
Objective Division: | Health |
Objective Group: | Public health (excl. specific population health) |
Objective Field: | Behaviour and health |
UTAS Author: | He, Y (Ms Ye He) |
UTAS Author: | Tian, J (Dr Jing Tian) |
UTAS Author: | Blizzard, L (Professor Leigh Blizzard) |
UTAS Author: | Oddy, WH (Professor Wendy Oddy) |
UTAS Author: | Dwyer, T (Professor Terry Dwyer) |
UTAS Author: | Venn, AJ (Professor Alison Venn) |
ID Code: | 137200 |
Year Published: | 2020 (online first 2019) |
Web of Science® Times Cited: | 2 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2020-02-05 |
Last Modified: | 2020-09-07 |
Downloads: | 0 |
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