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Lifetime risk factors for pre- and post-bronchodilator lung function decline: A population-based study


Bui, DS and Perret, JL and Walters, EH and Abramson, MJ and Burgess, JA and Bui, MQ and Bowatte, G and Lowe, AJ and Russell, MA and Alif, SM and Thompson, BR and Hamilton, GS and Giles, GG and Thomas, PS and Morrison, S and Johns, DP and Knibbs, LD and Zock, JP and Marcon, A and Garcia-Aymerich, J and Erbas, B and Jarvis, D and Svanes, C and Lodge, CJ and Dharmage, SC, Lifetime risk factors for pre- and post-bronchodilator lung function decline: A population-based study, Annals of the American Thoracic Society, 17, (3) pp. 302-312. ISSN 2325-6621 (2020) [Refereed Article]

Copyright Statement

Copyright 2020 by the American Thoracic Society

DOI: doi:10.1513/AnnalsATS.201904-329OC


Rationale: Interactions between early life and adult insults on lung function decline are not well understood, with most studies investigating prebronchodilator (pre-BD) FEV1 decline.

Objectives: To investigate relationships between adult risk factors and pre- and post-BD lung function decline and their potential effect modification by early life and genetic factors.

Methods: Multiple regression was used to examine associations between adult exposures (asthma, smoking, occupational exposures, traffic pollution, and obesity) and decline in both pre- and post-BD spirometry (forced expiratory volume in 1 s [FEV1], forced vital capacity [FVC], and FEV1/FVC) between ages 45 and 53 years in the Tasmanian Longitudinal Health Study (n = 857). Effect modification of these relationships by childhood respiratory risk factors, including low childhood lung function and GST (glutathione S-transferase) gene polymorphisms, was investigated.

Results: Baseline asthma, smoking, occupational exposure to vapors/gases/dusts/fumes, and living close to traffic were associated with accelerated decline in both pre- and post-BD FEV1. These factors were also associated with FEV1/FVC decline. Occupational exposure to aromatic solvents was associated with pre-BD but not post-BD FEV1 decline. Maternal smoking accentuated the effect of personal smoking on pre- and post-BD FEV1 decline. Lower childhood lung function and having the GSTM1 null allele accentuated the effect of occupational exposure to vapors/gases/ dusts/fumes and personal smoking on post-BD FEV1 decline. Incident obesity was associated with accelerated decline in FEV1 and more pronounced in FVC.

Conclusions: This study provides new evidence for accentuation of individual susceptibility to adult risk factors by low childhood lung function, GSTM1 genotype, and maternal smoking.

Item Details

Item Type:Refereed Article
Keywords:lung function, decline, interaction, bronchodilator, susceptibility
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Epidemiology not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Walters, EH (Professor Haydn Walters)
UTAS Author:Johns, DP (Associate Professor David Johns)
ID Code:137003
Year Published:2020
Funding Support:National Health and Medical Research Council (299901)
Web of Science® Times Cited:15
Deposited By:Medicine
Deposited On:2020-01-28
Last Modified:2021-09-02

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