Genetic variants in TEX15 gene conferred susceptibility to spermatogenic failure in the Chinese Han population
Ruan, J and He, X-J and Du, W-D and Chen, G and Zhou, Y and Xu, S and Zuo, X-B and Fang, L-B and Cao, Y-X and Zhang, X-J, Genetic variants in TEX15 gene conferred susceptibility to spermatogenic failure in the Chinese Han population, Reproductive Sciences, 19, (11) pp. 1190-1196. ISSN 1933-7191 (2012) [Refereed Article]
This study aimed to analyze the distribution of single-nucleotide polymorphisms (SNPs) of testis-expressed 15 (TEX15) gene in the Chinese Han infertile men and fertile men. This case-control study comprised 309 infertile men with nonobstructive azoospermia (NOA, n = 199) or severe oligozoospermia (SO, n = 110) and 377 fertile controls. Six SNPs were genotyped by Sequenom iplex technology. The results showed that the variants rs323346 and rs323347 contributed to the increasing risk of SO (P = .041, odds ratio [OR] = 1.635, 95% confidence interval [CI] = 1.018-2.628 and P = .046, OR = 1.616, 95% CI = 1.006-2.597). The haplotype AT of the SNPs rs323347 and rs323346 could reduce risk in the patients with SO (P = .040, OR = 0.616, and 95% CI = 0.383-0.990). The haplotype GC of the variants rs323347 and rs323346 conferred a significantly increased risk of SO (P = .040, OR = 1.624, 95% CI = 1.010-2.610). Thus, the polymorphisms rs323346 and rs323347 of the TEX15 gene could be considered the genetic risk factors for spermatogenic failure in the Chinese Han population.
genetics, spermatogenic failure, male infertility, TEX15 gene, SNPs, spermatogenesis