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EZH2 genetic variants affect risk of gastric cancer in the Chinese Han population

Citation

Zhou, Y and Du, WD and Wu, Q and Liu, Y and Chen, G and Ruan, J and Xu, S and Yang, F and Zhou, FS and Tang, XF and Tang, HY and Zuo, XB and Zhang, FY and Sun, LD and Zhang, XJ, EZH2 genetic variants affect risk of gastric cancer in the Chinese Han population, Molecular Carcinogenesis, 53, (8) pp. 589-597. ISSN 0899-1987 (2014) [Refereed Article]

Copyright Statement

Copyright 2012 Wiley Periodicals, Inc.

DOI: doi:10.1002/mc.21871

Abstract

Enhancer of zeste 2 (EZH2) gene encodes a histone methyltransferase that constitutes the catalytic component of the polycomb repressive complex-2 (PRC2) to initiate epigenetic silencing of genes. It is reported that the expression level of EZH2 in gastric cancer tissue was highly correlated with tumor progression, however, whether EZH2 genetic variants were associated with the risk of gastric cancer remains yet unknown. In this study, we conducted a genotyping analysis for EZH2 in 311 cases of gastric cancer and 425 controls from the Chinese Han population. We found five single nucleotide polymorphisms (SNP; rs12670401, rs6464926, rs2072407, rs734005, and rs734004) of EZH2 gene were significantly associated with the risk of gastric cancer. Of which, the rs12670401 with the minor allele C and rs6464926 with the minor allele T revealed strong associations with increased gastric cancer risk [P 0.009, adjusted odds ratio (aOR) 1.327, 95% CI 1.0751.683 and P 0.012, aOR 1.310, 95% CI 1.0591.619]. The other three SNPs, rs2072407, rs734005, and rs734004 contributed to significantly reduced risk of gastric cancer (P 0.033, aOR 0.787, 95% CI 0.6330.981, P 0.045, aOR 0.799, 95% CI 0.6420.995 and P 0.048, aOR 0.803, 95% CI 0.6450.999), respectively. We further found that rs12670401 and rs6464926 were in a strong LD while rs2072407, rs734005, and rs734004 were in another. Haplotype analysis of the five SNPs showed that haplotype CCTCT reduced the risk of gastric cancer (P 0.031 and aOR 0.784), while haplotype GTCTC significantly elevated the risk of gastric cancer (P 0.011 and aOR 1.310). We concluded that EZH2 variants were significantly associated with gastric cancer risk. Our results for the first time provided new insight into susceptibility factors of EZH2 gene variants in carcinogenesis of gastric cancer of the Chinese Han population.

Item Details

Item Type:Refereed Article
Keywords:EZH2, gastric cancer, single nucleotide polymorphism
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Genomics
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Zhou, Y (Mr Yuan Zhou)
ID Code:136943
Year Published:2014
Web of Science® Times Cited:13
Deposited By:Menzies Institute for Medical Research
Deposited On:2020-01-23
Last Modified:2020-06-10
Downloads:0

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