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Adverse drug reactions to antiretroviral drugs and impact on treatment adherence among HIV patients in northwestern Nigeria

Citation

Isa, AM and Abubakar, IJ and Chedi, BAZ, Adverse drug reactions to antiretroviral drugs and impact on treatment adherence among HIV patients in northwestern Nigeria, Drugs and Therapy Perspectives, 34 pp. 488-495. ISSN 1172-0360 (2018) [Refereed Article]

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DOI: doi:10.1007/s40267-018-0546-7

Abstract

Background: Adverse drug reactions (ADRs) related to antiretroviral therapy (ART) have been a healthcare concern in the management of HIV. Information relating to ADR prevalence and its contribution to medication adherence is still limited in the northwestern part of Nigeria.

Objective: The aim of this study was to determine the prevalence of ADRs related to ART use, and its association with non-adherence to treatment.

Methods: A prospective observational study was conducted among HIV patients receiving ART at the ART unit of a specialist hospital in Jigawa State, the Northwestern region of Nigeria. Data were collected using patient interview and medical case folders. Patients were followed for 6 months for ADR monitoring. ADR causality was assessed using the WHO causality assessment.

Results: Of the 167 patients in the study, 98 (58.7%) reported experiencing ADRs from ART use. Thirty-nine (44.8%) of the ADRs were possible, 16 (18.4%) were probable, 23 (26.4%) were unlikely, and 9 (10.3%) were conditional. Forty-one (47.1%) of the ADRs were mild, 45 (51.7%) were moderate, and 1 (1.2%) was severe. The most commonly reported ADRs were related to the CNS (163, 52%). ADRs led to non-adherence in 16 patients (16.3%) in the study (Chi-square = 12.1; p < 0.001).

Conclusion: The occurrence of ADRs associated with the use of ART is common and leads to non-adherence to ART among HIV patients. Adequate patient adherence counselling is therefore needed to improve adherence to ART, in addition to patient education and clinical interventions to manage ADRs.

Item Details

Item Type:Refereed Article
Keywords:adverse drug events, HIV
Research Division:Medical and Health Sciences
Research Group:Pharmacology and Pharmaceutical Sciences
Research Field:Toxicology (incl. Clinical Toxicology)
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Medical and Health Sciences
UTAS Author:Abubakar, IJ (Mr Ibrahim Jatau Abubakar)
ID Code:136722
Year Published:2018
Deposited By:Pharmacy
Deposited On:2020-01-15
Last Modified:2020-02-11
Downloads:0

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