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Dispersal of Mycobacterium tuberculosis Driven by Historical European Trade in the South Pacific
Citation
Mulholland, CV and Shockey, AC and Aung, HL and Cursons, RT and O'Toole, RF and Gautam, SS and Brites, D and Gagneux, S and Roberts, SA and Karalus, N and Cook, GM and Pepperell, CS and Arcus, VL, Dispersal of Mycobacterium tuberculosis Driven by Historical European Trade in the South Pacific, Frontiers in Microbiology, 10 Article 2778. ISSN 1664-302X (2019) [Refereed Article]
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DOI: doi:10.3389/fmicb.2019.02778
Abstract
Mycobacterium tuberculosis (Mtb) is a globally distributed bacterial pathogen whose
population structure has largely been shaped by the activities of its obligate human host.
Oceania was the last major global region to be reached by Europeans and is the last
region for which the dispersal and evolution of Mtb remains largely unexplored. Here,
we investigated the evolutionary history of the Euro-American L4.4 sublineage and its
dispersal to the South Pacific. Using a phylodynamics approach and a dataset of 236
global Mtb L4.4 genomes we have traced the origins and dispersal of L4.4 strains to
New Zealand. These strains are predominantly found in indigenous Maori and Pacific ¯
people and we identify a clade of European, likely French, origin that is prevalent in
indigenous populations in both New Zealand and Canada. Molecular dating suggests
the expansion of European trade networks in the early 19th century drove the dispersal
of this clade to the South Pacific. We also identify historical and social factors within
the region that have contributed to the local spread and expansion of these strains,
including recent Pacific migrations to New Zealand and the rapid urbanization of Maori ¯
in the 20th century. Our results offer new insight into the expansion and dispersal of Mtb
in the South Pacific and provide a striking example of the role of historical European
migrations in the global dispersal of Mtb.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | tuberculosis, pathogen, phylodynamics, phylogeography, indigenous people, Pacific, New Zealand |
| Research Division: | Medical and Health Sciences |
| Research Group: | Clinical Sciences |
| Research Field: | Infectious Diseases |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Infectious Diseases |
| UTAS Author: | O'Toole, RF (Dr Ronan O'Toole) |
| UTAS Author: | Gautam, SS (Mr Sanjay Gautam) |
| ID Code: | 136720 |
| Year Published: | 2019 |
| Deposited By: | Medicine |
| Deposited On: | 2020-01-15 |
| Last Modified: | 2020-01-15 |
| Downloads: | 0 |
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