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Dispersal of Mycobacterium tuberculosis Driven by Historical European Trade in the South Pacific

Citation

Mulholland, CV and Shockey, AC and Aung, HL and Cursons, RT and O'Toole, RF and Gautam, SS and Brites, D and Gagneux, S and Roberts, SA and Karalus, N and Cook, GM and Pepperell, CS and Arcus, VL, Dispersal of Mycobacterium tuberculosis Driven by Historical European Trade in the South Pacific, Frontiers in Microbiology, 10 Article 2778. ISSN 1664-302X (2019) [Refereed Article]


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Copyright Statement

Copyright © 2019 Mulholland, Shockey, Aung, Cursons, O’Toole, Gautam, Brites, Gagneux, Roberts, Karalus, Cook, Pepperell and Arcus. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

DOI: doi:10.3389/fmicb.2019.02778

Abstract

Mycobacterium tuberculosis (Mtb) is a globally distributed bacterial pathogen whose population structure has largely been shaped by the activities of its obligate human host. Oceania was the last major global region to be reached by Europeans and is the last region for which the dispersal and evolution of Mtb remains largely unexplored. Here, we investigated the evolutionary history of the Euro-American L4.4 sublineage and its dispersal to the South Pacific. Using a phylodynamics approach and a dataset of 236 global Mtb L4.4 genomes we have traced the origins and dispersal of L4.4 strains to New Zealand. These strains are predominantly found in indigenous Maori and Pacific ¯ people and we identify a clade of European, likely French, origin that is prevalent in indigenous populations in both New Zealand and Canada. Molecular dating suggests the expansion of European trade networks in the early 19th century drove the dispersal of this clade to the South Pacific. We also identify historical and social factors within the region that have contributed to the local spread and expansion of these strains, including recent Pacific migrations to New Zealand and the rapid urbanization of Maori ¯ in the 20th century. Our results offer new insight into the expansion and dispersal of Mtb in the South Pacific and provide a striking example of the role of historical European migrations in the global dispersal of Mtb.

Item Details

Item Type:Refereed Article
Keywords:tuberculosis, pathogen, phylodynamics, phylogeography, indigenous people, Pacific, New Zealand
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Infectious diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:O'Toole, RF (Dr Ronan O'Toole)
UTAS Author:Gautam, SS (Mr Sanjay Gautam)
ID Code:136720
Year Published:2019
Web of Science® Times Cited:5
Deposited By:Medicine
Deposited On:2020-01-15
Last Modified:2020-05-22
Downloads:2 View Download Statistics

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