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Understanding adverse drug-related emergency department visits: development of a conceptual model through a systematic review


Jatau, AI and Shitu, Z and Khalid, GM and Yunusa, I and Awaisu, A, Understanding adverse drug-related emergency department visits: development of a conceptual model through a systematic review, Therapeutic advances in drug safety pp. 1-8. ISSN 2042-0986 (2019) [Refereed Article]


Copyright Statement

Copyright 2019 The Authors. Licensed under Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

DOI: doi:10.1177/2042098619852552


Background: The burden of adverse drug event (ADE)-related emergency department (ED) visits is increasing despite several preventive measures. The objective of this paper was to develop and validate a conceptual model for a better understanding of ADE-related ED visits and to guide the design and implementation of effective interventions.

Methods: The development of the model involved a systematic review of the literature using PubMed and Embase databases. Studies reporting the risk factors associated with ADE-related ED visits were included. The methodological qualities of the included studies were assessed using the Mixed Methods Appraisal Tool (MMAT). The model was mapped and validated using face and content validity by an expert panel. Deficiencies and targeted interventions were identified, and steps for the design and implementation were recommended.

Results: The literature search generated 1361 articles, of which 38 were included in the review; 41 risk factors associated with ADE-related ED visits were identified. All factors were mapped, and the model was validated through face and content validity. The model consisted of six concepts related to sociodemographic factors, clinical factors, ADE-related to ED visits, ADE while in the ED, outcomes, and consequences. Interventions could be targeted at the factors identified in each concept to prevent ADE-related ED burden.

Conclusion: A conceptual model to guide the successful design and implementation of strategies to prevent ADE-related ED visits and the occurrence of ADE at ED was developed. Clinicians should take these factors into consideration to prevent untoward events, especially when treating high-risk patients.

Item Details

Item Type:Refereed Article
Keywords:adverse drug events, drug-related problem, emergency department, pharmacoepidemiology
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Toxicology (incl. clinical toxicology)
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the health sciences
UTAS Author:Jatau, AI (Mr Ibrahim Jatau Abubakar)
ID Code:136719
Year Published:2019
Web of Science® Times Cited:4
Deposited By:Pharmacy
Deposited On:2020-01-15
Last Modified:2020-04-30
Downloads:15 View Download Statistics

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