File(s) under permanent embargo
Human pluripotent stem cells for the modelling of diseases of the retina and optic nerve: toward a retina in a dish
journal contribution
posted on 2023-05-20, 09:17 authored by Lidgerwood, GE, Alexander HewittAlexander Hewitt, Pebay, AHuman pluripotent stem cells can be differentiated into specific, relevant cell types of interest including the cells of the retina and optic nerve. These cells can then be used to study fundamental biology as well as disease modelling and subsequent screening of potential treatments. Many models of differentiation and modelling have relied on two-dimensional monocultures of specific cell types, which are not representative of the complexity of the human retina and optic nerve. Hence, more complex models of the human retina and optic nerve are required. Three-dimensional organoids and emerging cell culture methods may provide more physiologically relevant models to study developmental biology and pathology of the retina and optic nerve.
History
Publication title
Current Opinion in PharmacologyVolume
48Pagination
114-119ISSN
1471-4892Department/School
Menzies Institute for Medical ResearchPublisher
Elsevier Sci LtdPlace of publication
The Boulevard, Langford Lane, Kidlington, Oxford, England, Oxon, Ox5 1GbRights statement
Copyright 2019 Elsevier Ltd.Repository Status
- Restricted