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Effect of a 24-month physical activity program on brain changes in older adults at risk of Alzheimer's disease: the AIBL active trial

Citation

Venkatraman, VK and Sanderson, A and Cox, KL and Ellis, KA and Steward, C and Phal, PM and Gorelik, A and Sharman, MJ and Villemagne, VL and Lai, M and Cyarto, EV and Merkel, B and Ames, D and Szoeke, C and Rowe, CC and Masters, CL and Lautenschlager, NT and Desmond, PM, Effect of a 24-month physical activity program on brain changes in older adults at risk of Alzheimer's disease: the AIBL active trial, Neurobiology of Aging pp. 1-10. ISSN 0197-4580 (2019) [Refereed Article]

Copyright Statement

Copyright 2019 Elsevier Inc.

DOI: doi:10.1016/j.neurobiolaging.2019.02.030

Abstract

White matter hyperintensities (WMHs) are a risk factor for cognitive decline. Physical activity (PA) is associated with lower WMH. Whether long-term exposure to PA programs has beneficial effects on WMH progression in older adults with memory complaints and comorbid conditions has had limited exploration. This study explored whether a 24-month moderate-intensity PA intervention can delay the progression of WMH and hippocampus loss in older adults at risk for cognitive decline. Data acquired on magnetic resonance imaging were used to measure the progression of WMH and hippocampus loss. The results of this study showed no effect of intervention on either the primary outcome measure "WMH" or the secondary outcome measure "hippocampal volume." In addition, neither beta amyloid status nor the adherence to the intervention had any effect on the outcome. In this cohort of subjective memory complaints and mild cognitive impairment participants with vascular risk factors, there was no effect of long-term moderate-intensity PA on WMH or hippocampal loss.

Item Details

Item Type:Refereed Article
Keywords:cognitive impairment, physical activity, hippocampal loss, white matter hyperintensity, intervention
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Sharman, MJ (Dr Matt Sharman)
ID Code:136551
Year Published:2019
Funding Support:National Health and Medical Research Council (APP1005942)
Web of Science® Times Cited:7
Deposited By:Health Sciences
Deposited On:2020-01-07
Last Modified:2020-03-30
Downloads:0

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