Melody, SM and Ford, JB and Wills, K and Venn, A and Johnston, FH, Maternal exposure to ﬁne particulate matter from a large coal mine ﬁre is associated with gestational diabetes mellitus: a prospective cohort study, Environmental Research Article 108956. ISSN 0013-9351 (2019) [Refereed Article]
Methods: We defined a complete cohort of pregnant women with births >20 weeks in the Latrobe Valley from March 1, 2012-Dec 31, 2015 utilising administrative perinatal data. Average and peak fine particulate matter (PM2.5) was assigned to residential address at delivery using a chemical transport model. Maternal, meteorological and temporal variables were included in final log-binomial regression models.
Results: 3612 singleton pregnancies were included in the analysis; 766 were exposed to the smoke event. Average maternal PM2.5 exposure was 4.4 μg/m3 (SD 7.7; IQR 2.12). Average peak PM2.5 exposure was 44.9 μg/m3 (SD 57.1; IQR 35.0). An interquartile range increase in peak PM2.5 was associated with a 16% increased likelihood of gestational diabetes mellitus (95%CI 1.09, 1.22; <0.0001). Whereas, an interquartile range increase in average PM2.5 was associated with a 7% increased likelihood of gestational diabetes mellitus (95%CI 1.03, 1.10; <0.0001). Second trimester exposure was of critical importance. No association for hypertensive disorders or abnormal placentation was observed.
Conclusion: This is the first study to examine obstetric complications relating to a discrete smoke event. These findings may guide the public health response to future similar events.
|Item Type:||Refereed Article|
|Keywords:||air pollution, pregnancy complications, gestational diabetes, coal mine fire|
|Research Division:||Medical and Health Sciences|
|Research Group:||Public Health and Health Services|
|Research Field:||Environmental and Occupational Health and Safety|
|Objective Group:||Public Health (excl. Specific Population Health)|
|Objective Field:||Environmental Health|
|UTAS Author:||Melody, SM (Dr Shannon Melody)|
|UTAS Author:||Wills, K (Dr Karen Wills)|
|UTAS Author:||Venn, A (Professor Alison Venn)|
|UTAS Author:||Johnston, FH (Associate Professor Fay Johnston)|
|Funding Support:||National Health and Medical Research Council (APP1150324)|
|Deposited By:||Menzies Institute for Medical Research|
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