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Inorganic particulate matter modulates non-typeable Haemophilus influenzae growth: a link between chronic bacterial infection and geogenic particles
Citation
Williams, L and Tristram, SG and Zosky, GR, Inorganic particulate matter modulates non-typeable Haemophilus influenzae growth: a link between chronic bacterial infection and geogenic particles, Environmental Geochemistry and Health pp. 1-9. ISSN 0269-4042 (2019) [Refereed Article]
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Copyright Statement
Copyright 2019 Springer Nature B.V.
DOI: doi:10.1007/s10653-019-00492-3
Abstract
Australian Aboriginal populations have unacceptably high rates of bronchiectasis. This disease burden is associated with high rates of detection of pathogenic bacteria, particularly non-typeable Haemophilus influenzae (NTHi). While there is evidence to suggest that exposure to inorganic particulate matter (PM) is associated with worse respiratory infections, no studies have considered the direct effect of this PM on bacterial growth. Nine clinical isolates of pathogenic NTHi were used for this study. Isolates were exposed to two common iron oxides, haematite (Fe2O3) or magnetite (Fe3O4), or quartz (SiO2), as the main constituents of environmental inorganic PM. NTHi isolates were exposed to PM with varying levels of heme to identify whether the response to PM was altered by iron availability. The maximal rate of growth and maximum supported growth were assessed. We observed that inorganic PM was able to modify the maximal growth of selected NTHi isolates. Magnetite and quartz were able to increase maximal growth, while haematite could both increase and suppress the maximal growth. However, these effects varied depending on iron availability and on the bacterial isolate. Our data suggest that inorganic PM may directly alter the growth of pathogenic NTHi. This observation may partly explain the link between exposure to high levels of crustal PM and chronic bacterial infection in Australian Aboriginals.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | particulate matter, iron oxide, Haemophilus influenzae, bacterial growth, Aboriginal children, bronchiectasis, heme, iron, lung infection |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Cardiovascular medicine and haematology |
| Research Field: | Respiratory diseases |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Williams, L (Mr Lewis Williams) |
| UTAS Author: | Tristram, SG (Dr Stephen Tristram) |
| UTAS Author: | Zosky, GR (Professor Graeme Zosky) |
| ID Code: | 136392 |
| Year Published: | 2019 |
| Web of Science® Times Cited: | 3 |
| Deposited By: | Medicine |
| Deposited On: | 2019-12-18 |
| Last Modified: | 2022-08-25 |
| Downloads: | 14 View Download Statistics |
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