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Measuring the interaction between the macro- and micro-vasculature


Climie, RE and Gallo, A and Picone, DS and Di Lascio, N and van Sloten, TT and Guala, A and Mayer, CC and Hametner, B and Bruno, RM, Measuring the interaction between the macro- and micro-vasculature, Frontiers in Cardiovascular Medicine, 6 Article 169. ISSN 2297-055X (2019) [Refereed Article]

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DOI: doi:10.3389/fcvm.2019.00169


Structural and functional dysfunction in both the macro- and microvasculature are a feature of essential hypertension. In a healthy cardiovascular system, the elastic properties of the large arteries ensure that pulsations in pressure and flow generated by cyclic left ventricular contraction are dampened, so that less pulsatile pressure and flow are delivered at the microvascular level. However, in response to aging, hypertension, and other disease states, arterial stiffening limits the buffering capacity of the elastic arteries, thus exposing the microvasculature to increased pulsatile stress. This is thought to be particularly pertinent to high flow/low resistance organs such as the brain and kidney, which may be sensitive to excess pressure and flow pulsatility, damaging capillary networks, and resulting in target organ damage. In this review, we describe the clinical relevance of the pulsatile interaction between the macro- and microvasculature and summarize current methods for measuring the transmission of pulsatility between the two sites.

Item Details

Item Type:Refereed Article
Keywords:methods, microvascular, macrovascular, wave intensity analysis, brain, kidney, retina
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Cardiology (incl. Cardiovascular Diseases)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
UTAS Author:Climie, RE (Miss Rachel Climie)
UTAS Author:Picone, DS (Mr Dean Picone)
ID Code:136336
Year Published:2019
Web of Science® Times Cited:1
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-12-16
Last Modified:2020-01-14

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