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The development and validation of a human screening model of tobacco abstinence


Grabski, M and Curran, HV and Nutt, DJ and Husbands, SM and Ferguson, SG and Munafo, MR, The development and validation of a human screening model of tobacco abstinence, Drug and Alcohol Dependence, 206 pp. 1-7. ISSN 0376-8716 (2020) [Refereed Article]

Copyright Statement

2019 Published by Elsevier B.V.

DOI: doi:10.1016/j.drugalcdep.2019.107720


Introduction: Given the low efficacy of smoking cessation methods, an experimental medicine model indicating smoking abstinence would be of great benefit to the development of new treatments. Hence the sensitivity of cognitive tasks and ambulatory craving measures to smoking abstinence were investigated.

Methods: Cognitive tasks and ambulatory ratings of craving were assessed for sensitivity to acute abstinence (experiment 1), and nicotine replacement therapy administration (NRT) (experiment 2).

Results: In experiment 1 go/no-go performance was improved (Mean Difference [MD] -0.99, 95% CI: −1.90 to −0.08) and craving was lower (Regression Coefficient [RC] −33.39, 95% CI: -39.96 to -26.82) in satiated compared with abstinent smokers. There was no clear evidence that N-back (MD 0.64, 95% CI: −0.42 to 2.51), delay discounting (MD 0.01, 95% CI: 0.001 to 0.005) or dot probe performance (MD 0.61, 95% CI: −0.87 to 1.54) were sensitive to acute abstinence. In experiment 2 go/no-go performance was improved (MD 1.12, 95% CI: 0.162.08) and craving was lower (RC −18.59, 95% CI: −24.63 to −12.55) smokers abstinent overnight receiving NRT compared with placebo. There was no clear evidence that N-back (MD −0.25, 95% CI: −1.45 to 0.94), delay discounting (MD 0.01, 95% CI: -0.002 to 0.004) or dot probe performance (MD −0.49, 95% CI: −1.61 to −0.64) were sensitive to NRT.

Conclusions: Findings from two experiments converge to suggest that abstinence in smokers reliably increases ambulatory craving assessments and, to a lesser extent, decreases go/no-go task performance. These findings can be utilized in the development of an experimental medicine model to test novel treatments for smoking cessation.

Item Details

Item Type:Refereed Article
Keywords:tobacco withdrawal, tobacco abstinence, cognitive performance, ecological momentary assessment, smoking cessation, experimental medicine model
Research Division:Psychology
Research Group:Clinical and health psychology
Research Field:Health psychology
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Behaviour and health
UTAS Author:Ferguson, SG (Professor Stuart Ferguson)
ID Code:136301
Year Published:2020
Deposited By:Medicine
Deposited On:2019-12-13
Last Modified:2020-04-20

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