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microRNAs are key regulators in chronic lung disease: Exploring the vital link between disease progression and lung cancer

Citation

Eapen, MS and McAlinden, KD and Myers, S and Lu, W and Sohal, SS, microRNAs are key regulators in chronic lung disease: Exploring the vital link between disease progression and lung cancer, Journal of Clinical Medicine, 8, (11) Article 1986. ISSN 2077-0383 (2019) [Refereed Article]


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Copyright Statement

Copyright 2019 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.3390/jcm8111986

Abstract

microRNAs (miRNAs) bind to mRNAs and inhibit their expression through post-transcriptionally regulating gene expression. Here, we elaborate upon the concise summary of the role of miRNAs in carcinogenesis with specific attention to precursor respiratory pathogenesis caused by cigarette smoke modulation of these miRNAs. We review how miRNAs are implicated in cigarette-smoke-driven mechanisms, such as epithelial to mesenchymal transition, autophagy modulation, and lung ageing, which are important in the development of chronic obstructive pulmonary disease and potential progression to lung cancer. Extracellular vesicles are key to inter-cellular communication and sharing of miRNAs. A deeper understanding of the role of miRNAs in chronic respiratory disease and their use as clinical biomarkers has great potential. Therapeutic targeting of miRNAs may significantly benefit the prevention of cancer progression.

Item Details

Item Type:Refereed Article
Keywords:microRNAs, COPD, epithelium, fibrosis, EMT, lung cancer, ICS, inflammation
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
UTAS Author:Eapen, MS (Mr Mathew Eapen)
UTAS Author:McAlinden, KD (Mr Kielan McAlinden)
UTAS Author:Myers, S (Dr Stephen Myers)
UTAS Author:Lu, W (Dr Monica Lu)
UTAS Author:Sohal, SS (Dr Sukhwinder Sohal)
ID Code:136062
Year Published:2019
Deposited By:Health Sciences
Deposited On:2019-11-28
Last Modified:2020-03-30
Downloads:0

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