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Potassium efflux fires the canon: Potassium efflux as a common trigger for canonical and noncanonical NLRP3 pathways
Citation
Rivers-Auty, J and Brough, D, Potassium efflux fires the canon: Potassium efflux as a common trigger for canonical and noncanonical NLRP3 pathways, European journal of immunology, 45, (10) pp. 2758-2761. ISSN 0014-2980 (2015) [Refereed Article]
 | PDF (Rivers-Auty J, Brough D, 2015. Potassium efflux fires the canon: Potassium efflux as a common trigger for canonical and noncanonical NLRP3 pathways. European Journal of Immunology. 45: 2758-61.) 662Kb |
Copyright Statement
© 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is the pre-peer reviewed version which has been published in final form at the DOI below. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Official URL: https://www.ncbi.nlm.nih.gov/pubmed/26332156
DOI: doi:10.1002/eji.201545958
Abstract
Murine caspase-11 and its human orthologues, caspase-4 and caspase-5, activate an inflammatory response following cytoplasmic recognition of cell wall constituents from Gram-negative bacteria, such as LPS. This inflammatory response involves pyroptotic cell death and the concomitant release of IL-1α, as well as the production of IL-1β and IL-18 through the noncanonical NLR family, pyrin domain containing 3 (NLRP3) pathway. This commentary discusses three papers in this issue of the European Journal of Immunology that advance our understanding of the roles of caspase-11, -4, and -5 in the noncanonical pathway. By utilizing the new gene editing technique, clustered regularly interspaced short palindromic repeats (CRISPR), as well as sensitive cell imaging techniques, these papers establish that cytoplasmic LPS-dependent IL-1β production requires the NLRP3 inflammasome and that its activation is dependent on K(+) efflux, whereas IL-1α release and pyroptotic cell death pathways are NLRP3-independent. These findings expand on previous research implicating K(+) efflux as the principal trigger for NLRP3 activation and suggest that canonical and noncanonical NLRP3 pathways are not as dissimilar as first thought.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | Interleukin1, protein function, inflammation, cell biology |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Immunology |
| Research Field: | Innate immunity |
| Objective Division: | Health |
| Objective Group: | Specific population health (excl. Indigenous health) |
| Objective Field: | Health related to ageing |
| UTAS Author: | Rivers-Auty, J (Dr Jack Auty) |
| ID Code: | 135939 |
| Year Published: | 2015 |
| Web of Science® Times Cited: | 35 |
| Deposited By: | Medicine |
| Deposited On: | 2019-11-21 |
| Last Modified: | 2019-12-13 |
| Downloads: | 12 View Download Statistics |
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