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Redefining the ancestral origins of the interleukin-1 superfamily


Rivers-Auty, J and Daniels, MJD and Colliver, I and Roberston, DL and Brough, D, Redefining the ancestral origins of the interleukin-1 superfamily, Nature Communications, 9 pp. 1-12. ISSN 2041-1723 (2018) [Refereed Article]


Copyright Statement

Copyright 2018 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

DOI: doi:10.1038/s41467-018-03362-1


The interleukin-1 (IL-1) receptor and ligand families are components of the immune system. Knowledge of their evolutionary history is essential to understand their function. Using chromosomal anatomy and sequence similarity, we show that IL-1 receptor family members are related and nine members are likely formed from duplication and modification of a proto-IL-1R1 receptor. The IL-1 ligands have a different evolutionary history. The first proto-IL-1β gene coincided with proto-IL-1R1 and duplication events resulted in the majority of IL-1 ligand family members. However, large evolutionary distances are observed for IL-1α, IL-18 and IL-33 proteins. Further analysis show that IL-33 and IL-18 have poor sequence similarity and no chromosomal evidence of common ancestry with the IL-1β cluster and therefore should not be included in the IL-1 ligand ancestral family. IL-1α formed from the duplication of IL-1β, and moonlighting functions of pro-IL-1α acted as divergent selection pressures for the observed sequence dissimilarity.

Item Details

Item Type:Refereed Article
Keywords:Interleukin1, protein function, protein evolution
Research Division:Biomedical and Clinical Sciences
Research Group:Immunology
Research Field:Innate immunity
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biological sciences
UTAS Author:Rivers-Auty, J (Dr Jack Auty)
ID Code:135831
Year Published:2018
Web of Science® Times Cited:41
Deposited By:Medicine
Deposited On:2019-11-15
Last Modified:2019-12-12
Downloads:18 View Download Statistics

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