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Metabolic-vascular coupling in skeletal muscle: a potential role for capillary pericytes?

Citation

Attrill, E and Ramsay, C and Ross, R and Richards, S and Sutherland, BA and Keske, MA and Eringa, E and Premilovac, D, Metabolic-vascular coupling in skeletal muscle: a potential role for capillary pericytes?, Clinical and Experimental Pharmacology and Physiology, 47, (3) pp. 520-528. ISSN 0305-1870 (2019) [Refereed Article]


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Copyright Statement

2019 John Wiley & Sons Australia, Ltd. This is the peer reviewed version of the article which has been published in final form at the DOI below. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

DOI: doi:10.1111/1440-1681.13208

Abstract

The matching of capillary blood flow to metabolic rate of the cells within organs and tissues is a critical microvascular function which ensures appropriate delivery of hormones and nutrients, and the removal of waste products. This relationship is particularly important in tissues where local metabolism, and hence capillary blood flow, must be regulated to avoid a mismatch between nutrient demand and supply that would compromise normal function. The consequences of a mismatch in microvascular blood flow and metabolism are acutely apparent in the brain and heart, where a sudden cessation of blood flow, for example following an embolism, acutely manifests as stroke or myocardial infarction. Even in more resilient tissues such as skeletal muscle, a short-term mismatch reduces muscle performance and exercise tolerance, and can cause intermittent claudication. In the longer-term, a microvascular-metabolic mismatch in skeletal muscle reduces insulin-mediated muscle glucose uptake, leading to disturbances in whole body metabolic homeostasis. While the notion that capillary blood flow is fine tuned to meet cellular metabolism is well-accepted, the mechanisms that control this function and where and how different parts of the vascular tree contribute to capillary blood flow regulation remains poorly understood. Here, we discuss the emerging evidence implicating pericytes, mural cells that surround capillaries, as key mediators that match tissue metabolic demand with adequate capillary blood flow in a number of organs, including skeletal muscle.

Item Details

Item Type:Refereed Article
Keywords:capillary blood flow, microvasculature, pericytes, skeletal muscle
Research Division:Medical and Health Sciences
Research Group:Medical Physiology
Research Field:Systems Physiology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
UTAS Author:Attrill, E (Ms Emily Attrill)
UTAS Author:Ramsay, C (Mr Ciaran Ramsay)
UTAS Author:Ross, R (Dr Renee Ross)
UTAS Author:Richards, S (Dr Stephen Richards)
UTAS Author:Sutherland, BA (Dr Brad Sutherland)
UTAS Author:Premilovac, D (Dr Dino Premilovac)
ID Code:135791
Year Published:2019
Deposited By:Medicine
Deposited On:2019-11-14
Last Modified:2020-02-27
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