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Reassessing the Role of Diacylglycerols in Insulin Resistance
Citation
Jayasinghe, SU and Tankeu, AT and Amati, F, Reassessing the Role of Diacylglycerols in Insulin Resistance, Trends in Endocrinology and Metabolism ISSN 1043-2760 (2019) [Refereed Article]
Copyright Statement
© 2019 Elsevier Ltd. All rights reserved.
DOI: doi:10.1016/j.tem.2019.06.005
Abstract
Skeletal muscle (SM) insulin resistance (IR) plays an important role in the burden of
obesity, particularly because it leads to glucose intolerance and type 2 diabetes.
Among the mechanisms thought to link IR to obesity is the accumulation, in muscle
cells, of different lipid metabolites. Diacylglycerols (DAGs) are subject of particular
attention due to reported interactions with the insulin signaling cascade. Given
that SM accounts for the majority of insulin-stimulated glucose uptake, this review
integrates recent observational and mechanistic works with the sole focus on
questioning the role of DAGs in SM IR. Particular attention is given to the subcellular
distributions and specific structures of DAGs, highlighting future research directions towards reaching a consensus on the mechanistic role played by DAGs.
Item Details
Item Type: | Refereed Article |
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Keywords: | Lipids, Skeletal muscle, Insulin resistance |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Clinical sciences |
Research Field: | Endocrinology |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Jayasinghe, SU (Dr Sisitha Jayasinghe) |
ID Code: | 135784 |
Year Published: | 2019 |
Web of Science® Times Cited: | 15 |
Deposited By: | Health Sciences |
Deposited On: | 2019-11-13 |
Last Modified: | 2019-12-12 |
Downloads: | 0 |
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