Jayasinghe, SU and Torres, SJ and Nowson, CA and Tilbrook, AJ and Turner, AI, Cortisol, alpha amylase, blood pressure and heart rate responses to food intake in men aged 50-70 years: importance of adiposity, BMC Obesity, 1 Article 14. ISSN 2052-9538 (2014) [Refereed Article]
Copyright 2014 Jayasinghe et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Background: Increased adiposity is often associated with over activation of the hypothalamo-pituitary adrenal axis (HPA axis) and the sympatho-adrenal medullary system (SAM system) and excessive activation of these pathways in response to physiological challenges may be linked with the development of diseases. We tested the hypothesis that overweight/obese men aged 5070 years will have greater HPA axis and SAM system responses to food intake compared with age matched lean men.
Lean (Body Mass Index; BMI = 20-25 kg/m2; n = 19) and overweight/obese (BMI = 27-35 kg/m2; n = 17) men (5070 years) made their own lunch using standardised ingredients at 1200 h. Concentrations of cortisol and alpha amylase were measured in saliva samples collected every 15 min from 1145 h-1400 h with the exception of during lunch (1215 h) where no sample was collected. Blood pressures and heart rate were measured at 1145 h and every 15 minutes between 1245 h and 1400 h.
Results: Overweight/obese men had significantly higher body weight, BMI, percentage body fat and waist and hip circumferences compared to lean men (p < 0.001 for all). The meal consumed by the participants consisted of 22% protein, 53% carbohydrates and 25% fat. Overweight/obese men responded to lunch with a significant increase in cortisol whereas lean men did not show such an increase (time*treatment p = 0.008). There were no significant differences between the groups in the salivary alpha amylase response to the meal (time*treatment p = 0.195) or in SBP, DBP, MAP or HR responses (time*treatment p = 0.726, 0.898, 0.713, 0.620, respectively).
Conclusions: While men with a moderate level of overweight/obesity had a significant HPA axis response (as measured by salivary cortisol) to a standardised lunch, lean men had no HPA axis response. Lean and overweight/obese men had similar increases in SAM system activity (as measured by salivary alpha amylase) in response to the meal.
|Item Type:||Refereed Article|
|Keywords:||food intake, SAM system, HPA axis, obesity, adiposity, mens health, cortisol|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified|
|UTAS Author:||Jayasinghe, SU (Mr Sisitha Jayasinghe)|
|Deposited By:||Health Sciences|
|Downloads:||2 View Download Statistics|
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