Mahzabin, T and Pillow, JJ and Pinniger, GJ and Bakker, AJ and Noble, PB and White, RB and Karisnan, K and Song, Y, Influence of antenatal glucocorticoid on preterm lamb diaphragm, Pediatric Research, 82, (3) pp. 509-517. ISSN 0031-3998 (2017) [Refereed Article]
Copyright © 2017 International Pediatric Research Foundation, Inc.
Methods: Date-mated merino ewes received intramuscular injections of saline (control) or two doses of betamethasone (5.7 mg) at an interval of 24 h commencing either 2 or 14 days before delivery. Preterm lambs were killed after cesarean delivery at 121-day gestational age. In vitro contractile measurements were performed on the right hemidiaphragm, whereas molecular/cellular analyses used the left costal diaphragm.
Results: Different durations of fetal exposure to maternal betamethasone had no consistent effect on the protein metabolic pathway, expression of glucocorticoid receptor and its target genes, cellular oxidative status, or contractile properties of the fetal lamb diaphragm.
Conclusion: These data suggest that the potential benefits of betamethasone exposure on preterm respiratory function are not compromised by impaired diaphragm function after low-dose maternal intramuscular glucocorticoid exposure.
|Item Type:||Refereed Article|
|Keywords:||diaphragm dysfunction, steriod exposure, fetal develoment|
|Research Division:||Medical and Health Sciences|
|Research Group:||Paediatrics and Reproductive Medicine|
|Research Field:||Foetal Development and Medicine|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Respiratory System and Diseases (incl. Asthma)|
|UTAS Author:||Song, Y (Dr Yong Song)|
|Deposited By:||Menzies Institute for Medical Research|
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