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The implications of DNA methylation on food allergy

Citation

Lee, KH and Song, Y and O'Sullivan, M and Pereira, G and Loh, R and Zhang, GB, The implications of DNA methylation on food allergy, International Archives of Allergy and Immunology, 173, (4) pp. 183-192. ISSN 1018-2438 (2017) [Substantial Review]


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DOI: doi:10.1159/000479513

Abstract

Food allergy is a major clinical and public health concern worldwide. The risk factors are well defined, however, the mechanisms by which they affect immune development remain largely unknown, and unfortunately the effective treatment or prevention of food allergy is still being researched. Recent studies show that the genes that are critical for the development of food allergy are regulated through DNA methylation. Environmental factors can affect host DNA methylation status and subsequently predispose people to food allergy. DNA methylation is therefore an important mediator of gene-environment interactions in food allergy and key to understanding the mechanisms underlying the allergic development. Indeed, the modification and identification of the methylation levels of specific genetic loci have gained increasing attention for therapeutic and diagnostic application in combating food allergy. In this review, we summarize and discuss the recent developments of DNA methylation in food allergy, including the pathogenesis, therapy, and diagnosis. This review will also summarize and discuss the environmental factors that affect DNA methylation levels in food allergy.

Item Details

Item Type:Substantial Review
Keywords:DNA methylation, food allergy, gene expression, gene-environment interactions
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Epigenetics (incl. Genome Methylation and Epigenomics)
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Environmental Health
UTAS Author:Song, Y (Dr Yong Song)
ID Code:135697
Year Published:2017
Web of Science® Times Cited:2
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-11-08
Last Modified:2019-11-28
Downloads:0

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