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Environment changes genetic effects on respiratory conditions and allergic phenotypes
Citation
Song, Y and Schwager, MJ and Backer, V and Guo, J and Porsbjerg, C and Khoo, SK and Laing, IA and Moses, EK and LeSouef, P and Zhang, GB, Environment changes genetic effects on respiratory conditions and allergic phenotypes, Scientific Reports, 7, (1) Article 6342. ISSN 2045-2322 (2017) [Refereed Article]
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Copyright Statement
Copyright 2017 the authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
DOI: doi:10.1038/s41598-017-06791-y
Abstract
The prevalence of asthma and allergic diseases is disproportionately distributed among different populations, with an increasing trend observed in Western countries. Here we investigated how the environment affected genotype-phenotype association in a genetically homogeneous, but geographically separated population. We evaluated 18 single nucleotide polymorphisms (SNPs) corresponding to 8 genes (ADAM33, ALOX5, LT-α, LTC4S, NOS1, ORMDL3, TBXA2R and TNF-α), the lung function and five respiratory/allergic conditions (ever asthma, bronchitis, rhinitis, dermatitis and atopy) in two populations of Inuit residing either in the westernized environment of Denmark or in the rural area of Greenland. Our results showed that lung function was associated with genetic variants in ORMDL3, with polymorphisms having a significant interaction with place of residence. LT-α SNP rs909253 and rs1041981 were significantly associated with bronchitis risk. LT-α SNP rs2844484 was related to dermatitis susceptibility and was significantly influenced by the place of residence. The observed gene-phenotype relationships were exclusively present in one population and absent in the other population. We conclude that the genotype-phenotype associations relating to bronchitis and allergy susceptibility are dependent on the environment and that environmental factors/lifestyles modify genetic predisposition and change the genetic effects on diseases.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | environment effect, genetics, respiratory diseases, asthma and allergy |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Cardiovascular medicine and haematology |
| Research Field: | Respiratory diseases |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Song, Y (Dr Yong Song) |
| ID Code: | 135696 |
| Year Published: | 2017 |
| Web of Science® Times Cited: | 9 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2019-11-08 |
| Last Modified: | 2019-12-09 |
| Downloads: | 15 View Download Statistics |
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