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Cellular and molecular mechanisms of vitamin D in food allergy


Poole, A and Song, Y and Brown, H and Hart, PH and Zhang, GB, Cellular and molecular mechanisms of vitamin D in food allergy, Journal of Cellular and Molecular Medicine, 22, (7) pp. 3270-3277. ISSN 1582-1838 (2018) [Substantial Review]

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DOI: doi:10.1111/jcmm.13607


Food allergies are becoming increasingly prevalent, especially in young children. Epidemiological evidence from the past decade suggests a role of vitamin D in food allergy pathogenesis. Links have been made between variations in sunlight exposure, latitude, birth season and vitamin D status with food allergy risk. Despite the heightened interest in vitamin D in food allergies, it remains unclear by which exact mechanism(s) it acts. An understanding of the roles vitamin D plays within the immune system at the cellular and genetic levels, as well as the interplay between the microbiome and vitamin D, will provide insight into the importance of the vitamin in food allergies. Here, we discuss the effect of vitamin D on immune cell maturation, differentiation and function; microbiome; genetic and epigenetic regulation (eg DNA methylation); and how these processes are implicated in food allergies.

Item Details

Item Type:Substantial Review
Keywords:epigenetics, food allergy, genetics, microbiome, vitamin D
Research Division:Biomedical and Clinical Sciences
Research Group:Paediatrics
Research Field:Paediatrics not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Song, Y (Dr Yong Song)
ID Code:135693
Year Published:2018
Web of Science® Times Cited:14
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-11-08
Last Modified:2019-11-28

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