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Association of glucose homeostasis and metabolic syndrome with knee cartilage defects and cartilage volume in young adults

Citation

Meng, T and Antony, B and Venn, A and Fraser, B and Cicuttini, F and March, L and Cross, M and Dwyer, T and Jones, G and Laslett, LL and Ding, C, Association of glucose homeostasis and metabolic syndrome with knee cartilage defects and cartilage volume in young adults, Seminars in Arthritis and Rheumatism pp. 1-6. ISSN 0049-0172 (2019) [Refereed Article]

Copyright Statement

2019 Elsevier Inc.

DOI: doi:10.1016/j.semarthrit.2019.10.001

Abstract

Objective: To describe the associations of glucose homeostasis and metabolic syndrome (MetS) measures with knee cartilage defects and cartilage volume in young adults.

Methods: Fasting blood biochemistry, waist circumference and blood pressure measures were collected 45 years prior to knee magnetic resonance imaging (MRI) scans. Blood measures included levels of glucose, insulin, triglyceride and high-density lipoprotein cholesterol (HDL-C). Homeostatic model assessment 2-insulin resistance (HOMA2-IR), HOMA2-beta cell function (HOMA2-β), HOMA2-insulin sensitivity (HOMA-S) and MetS were calculated or defined. Knee cartilage defects and cartilage volume were measured from MRI scans. Data were analysed using log binomial or linear regressions.

Results: Among 328 participants (47.3% were females, aged 2636 years at baseline), 40 (12.7%) had hyperglycaemia and 21 (6.7%) had MetS. Glucose homeostasis measures (except fasting glucose) were associated with tibiofemoral cartilage defects (fasting insulin: relative risk (RR) 1.05, 95% confidence interval (CI) 1.01 to 1.08; HOMA2-IR: 1.44, 1.08 to 1.92; HOMA2-β: 2.59, 1.33 to 5.07; HOMA2-S: 0.36, 0.18 to 0.72), but not patellar cartilage defects. There were no associations between glucose homeostasis measures and knee cartilage volume. High waist circumference (RR 2.32, 95% CI 1.18 to 4.54) and low HDL-C (RR 1.99, 95% CI 1.08 to 3.69) were associated with tibiofemoral cartilage defects, but no other associations were observed between MetS or its components and cartilage defects or volume.

Conclusion: Insulin resistance, high waist circumference and low HDL-C were associated with higher risk of tibiofemoral cartilage defects, suggesting glucose homeostasis and some MetS components may affect early cartilage damage in young adults.

Item Details

Item Type:Refereed Article
Keywords:glucose homeostasis, metabolic syndrome, knee cartilage, young adults
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
UTAS Author:Meng, T (Mr Tao Meng)
UTAS Author:Antony, B (Dr Benny Eathakkattu Antony)
UTAS Author:Venn, A (Professor Alison Venn)
UTAS Author:Fraser, B (Dr Brooklyn Fraser)
UTAS Author:Dwyer, T (Professor Terry Dwyer)
UTAS Author:Jones, G (Professor Graeme Jones)
UTAS Author:Laslett, LL (Dr Laura Laslett)
UTAS Author:Ding, C (Professor Chang-Hai Ding)
ID Code:135610
Year Published:2019
Web of Science® Times Cited:2
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-11-05
Last Modified:2019-12-04
Downloads:0

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