Meng, T and Antony, B and Venn, A and Fraser, B and Cicuttini, F and March, L and Cross, M and Dwyer, T and Jones, G and Laslett, LL and Ding, C, Association of glucose homeostasis and metabolic syndrome with knee cartilage defects and cartilage volume in young adults, Seminars in Arthritis and Rheumatism pp. 1-6. ISSN 0049-0172 (2019) [Refereed Article]
© 2019 Elsevier Inc.
Results: Among 328 participants (47.3% were females, aged 26–36 years at baseline), 40 (12.7%) had hyperglycaemia and 21 (6.7%) had MetS. Glucose homeostasis measures (except fasting glucose) were associated with tibiofemoral cartilage defects (fasting insulin: relative risk (RR) 1.05, 95% confidence interval (CI) 1.01 to 1.08; HOMA2-IR: 1.44, 1.08 to 1.92; HOMA2-β: 2.59, 1.33 to 5.07; HOMA2-S: 0.36, 0.18 to 0.72), but not patellar cartilage defects. There were no associations between glucose homeostasis measures and knee cartilage volume. High waist circumference (RR 2.32, 95% CI 1.18 to 4.54) and low HDL-C (RR 1.99, 95% CI 1.08 to 3.69) were associated with tibiofemoral cartilage defects, but no other associations were observed between MetS or its components and cartilage defects or volume.
Conclusion: Insulin resistance, high waist circumference and low HDL-C were associated with higher risk of tibiofemoral cartilage defects, suggesting glucose homeostasis and some MetS components may affect early cartilage damage in young adults.
|Item Type:||Refereed Article|
|Keywords:||glucose homeostasis, metabolic syndrome, knee cartilage, young adults|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Research Field:||Rheumatology and Arthritis|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Skeletal System and Disorders (incl. Arthritis)|
|UTAS Author:||Meng, T (Mr Tao Meng)|
|UTAS Author:||Antony, B (Dr Benny Eathakkattu Antony)|
|UTAS Author:||Venn, A (Professor Alison Venn)|
|UTAS Author:||Fraser, B (Miss Brooklyn Fraser)|
|UTAS Author:||Dwyer, T (Professor Terry Dwyer)|
|UTAS Author:||Jones, G (Professor Graeme Jones)|
|UTAS Author:||Laslett, LL (Dr Laura Laslett)|
|UTAS Author:||Ding, C (Professor Chang-Hai Ding)|
|Deposited By:||Menzies Institute for Medical Research|
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