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Tert-Butyldimethylsilyl Amine (TBDMS-NH2): A Mild and Green Reagent for the Protection of Benzyl Alcohols, Phenols, and Carboxylic Acids under Solvent-Free Conditions

Citation

Duczynski, JA and Fuller, R and Stewart, SG, Tert-Butyldimethylsilyl Amine (TBDMS-NH2): A Mild and Green Reagent for the Protection of Benzyl Alcohols, Phenols, and Carboxylic Acids under Solvent-Free Conditions, Australian Journal of Chemistry, 69, (10) pp. 1172-1179. ISSN 0004-9425 (2016) [Refereed Article]

Copyright Statement

Copyright The Authors 2016

DOI: doi:10.1071/CH16097

Abstract

Herein, we present the use of the tert-butyldimethylsilyl amine (TBDMS-NH2) as a silylating reagent for phenols, benzyl alcohols, and carboxylic acids. Unlike other silyl protection reactions, this reported process with TBDMS-NH2 does not involve the formation of HCl. Importantly, we report the efficacy of this reagent in operating under solvent-free conditions and enabling short reaction times.

Item Details

Item Type:Refereed Article
Research Division:Chemical Sciences
Research Group:Organic Chemistry
Research Field:Organic Chemical Synthesis
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
UTAS Author:Fuller, R (Dr Rebecca Fuller)
ID Code:135605
Year Published:2016
Web of Science® Times Cited:1
Deposited By:Chemistry
Deposited On:2019-11-05
Last Modified:2019-12-13
Downloads:0

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