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Tert-Butyldimethylsilyl Amine (TBDMS-NH2): A Mild and Green Reagent for the Protection of Benzyl Alcohols, Phenols, and Carboxylic Acids under Solvent-Free Conditions
Citation
Duczynski, JA and Fuller, R and Stewart, SG, Tert-Butyldimethylsilyl Amine (TBDMS-NH2): A Mild and Green Reagent for the Protection of Benzyl Alcohols, Phenols, and Carboxylic Acids under Solvent-Free Conditions, Australian Journal of Chemistry, 69, (10) pp. 1172-1179. ISSN 0004-9425 (2016) [Refereed Article]
Copyright Statement
Copyright The Authors 2016
DOI: doi:10.1071/CH16097
Abstract
Herein, we present the use of the tert-butyldimethylsilyl amine (TBDMS-NH2) as a silylating reagent for phenols, benzyl alcohols, and carboxylic acids. Unlike other silyl protection reactions, this reported process with TBDMS-NH2 does not involve the formation of HCl. Importantly, we report the efficacy of this reagent in operating under solvent-free conditions and enabling short reaction times.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Chemical Sciences |
| Research Group: | Organic chemistry |
| Research Field: | Organic chemical synthesis |
| Objective Division: | Expanding Knowledge |
| Objective Group: | Expanding knowledge |
| Objective Field: | Expanding knowledge in the chemical sciences |
| UTAS Author: | Fuller, R (Dr Rebecca Fuller) |
| ID Code: | 135605 |
| Year Published: | 2016 |
| Web of Science® Times Cited: | 1 |
| Deposited By: | Chemistry |
| Deposited On: | 2019-11-05 |
| Last Modified: | 2019-12-13 |
| Downloads: | 0 |
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