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Reduced cortical somatostatin gene expression in a rat model of maternal immune activation
Citation
Duchatel, RJ and Harms, LR and Meehan, CL and Michie, PT and Bigland, MJ and Smith, DW and Jobling, P and Hodgson, DM and Tooney, PA, Reduced cortical somatostatin gene expression in a rat model of maternal immune activation, Psychiatry Research, 282 pp. 1-9. ISSN 0165-1781 (2019) [Refereed Article]
Copyright Statement
Crown Copyright © 2019 Published by Elsevier B.V. All rights reserved.
DOI: doi:10.1016/j.psychres.2019.112621
Abstract
Alterations in GABAergic interneurons and glutamic acid decarboxylase (GAD) are observed in the brains of
people with schizophrenia. Studies also show increased density of interstitial white matter neurons (IWMN),
including those containing GAD and somatostatin (SST) in the brain in schizophrenia. Maternal immune activation can be modelled in rodents to investigate the relationship between prenatal exposure to infections and
increased risk of developing schizophrenia. We reported that maternal immune activation induced an increase in
density of somatostatin-positive IWMN in the adult rat offspring. Here we hypothesised that maternal immune
activation induced in pregnant rats by polyinosinic:polycytidylic acid would alter SST and GAD gene expression
as well as increase the density of GAD-positive IWMNs in the adult offspring. SST gene expression was significantly reduced in the cingulate cortex of adult offspring exposed to late gestation maternal immune activation. There was no change in cortical GAD gene expression nor GAD-positive IWMN density in adults rats
exposed to maternal immune activation at either early or late gestation. This suggests that our model of maternal
immune activation induced by prenatal exposure of rats to polyinosinic:polycytidylic acid during late gestation is
able to recapitulate changes in SST but not other GABAergic neuropathologies observed in schizophrenia.
Item Details
Item Type: | Refereed Article |
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Keywords: | somatostatin, schizophrenia, maternal immune activation, cingulate cortex, white matter neuron |
Research Division: | Psychology |
Research Group: | Biological psychology |
Research Field: | Behavioural neuroscience |
Objective Division: | Expanding Knowledge |
Objective Group: | Expanding knowledge |
Objective Field: | Expanding knowledge in psychology |
UTAS Author: | Meehan, CL (Dr Crystal Meehan) |
ID Code: | 135589 |
Year Published: | 2019 |
Web of Science® Times Cited: | 5 |
Deposited By: | Psychology |
Deposited On: | 2019-11-04 |
Last Modified: | 2019-12-06 |
Downloads: | 0 |
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