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CORP: Practical tools for improving experimental design and reporting of laboratory studies of cardiovascular physiology and metabolism

Citation

Weeks, KL and Henstridge, DC and Salim, A and Shaw, JE and Marwick, TH and McMullen, JR, CORP: Practical tools for improving experimental design and reporting of laboratory studies of cardiovascular physiology and metabolism, American Journal of Physiology. Heart and Circulatory Physiology, 317, (3) pp. H627-H639. ISSN 1522-1539 (2019) [Refereed Article]


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2019 the American Physiological Society

DOI: doi:10.1152/ajpheart.00327.2019

Abstract

The exercise consisted of: 1) a short survey to acquire baseline data on current practices regarding the conduct of animal studies, 2) a series of presentations for promoting awareness and providing advice and practical tools for improving experimental design, and 3) a follow-up survey 12 mo later to assess whether practices had changed. The surveys were compulsory for responsible investigators (n = 16; paired data presented). Other investigators named on animal ethics applications were encouraged to participate (2017, total of 36 investigators; 2018, 37 investigators). The major findings to come from the exercise included 1) a willingness of investigators to make changes when provided with knowledge/tools and solutions that were relatively simple to implement (e.g., proportion of responsible investigators showing improved practices using a structured method for randomization was 0.44, 95% CI (0.19; 0.70), P = 0.003, and deidentifying drugs/interventions was 0.40, 95% CI (0.12; 0.68), P = 0.010); 2) resistance to change if this involved more personnel and time (e.g., as required for allocation concealment); and 3) evidence that changes to long-term practices ("habits") require time and follow-up. Improved practices could be verified based on changes in reporting within publications or documented evidence provided during laboratory visits. In summary, this exercise resulted in changed attitudes, practices, and reporting, but continued follow-up, monitoring, and incentives are required. Efforts to improve experimental rigor will reduce bias and will lead to findings with the greatest translational potential.

Item Details

Item Type:Refereed Article
Keywords:cardiovascular, diabetes, obesity
Research Division:Biological Sciences
Research Group:Physiology
Research Field:Animal Physiology - Systems
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
UTAS Author:Henstridge, DC (Mr Darren Henstridge)
ID Code:135557
Year Published:2019
Deposited By:Health Sciences
Deposited On:2019-11-01
Last Modified:2019-12-04
Downloads:0

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